Journal ArticleDOI
Materials for protein delivery in tissue engineering.
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The basic technology of controlled protein delivery using polymeric materials is outlined, and some of the techniques under investigation for the efficient administration of proteins in tissue engineering are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 1998-08-03. It has received 242 citations till now. The article focuses on the topics: Drug delivery.read more
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Novel crosslinking methods to design hydrogels
Wim E. Hennink,C.F. van Nostrum +1 more
TL;DR: In this overview, different chemical and physical crosslinking methods used for the design of biodegradable hydrogels are summarized and discussed.
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Polymeric biomaterials for tissue and organ regeneration
TL;DR: This paper reviews recent work involving polymeric biomaterials used for skin, cartilage, bone, vascular, nerve and liver regeneration, and the complexity of parameters involved in liver regeneration is presented.
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Controlled growth factor release from synthetic extracellular matrices.
TL;DR: A model delivery system that can respond to mechanical signalling and upregulate the release of a growth factor to promote blood vessel formation is reported, which may find a number of applications, including regeneration and engineering of new tissues and more general drug-delivery applications.
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Hydroxyapatite/poly(epsilon-caprolactone) composite coatings on hydroxyapatite porous bone scaffold for drug delivery.
TL;DR: The in vitro biodegradation of the composite coatings in the phosphate buffered saline solution increased linearly with incubation time and the rate differed with the coating concentration and the HA/PCL ratio; the higher concentration and HA amount caused the increased biodegrading.
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Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(epsilon-caprolactone) nanofibers for sustained release.
TL;DR: It was found that core-sheath nanofibers PCL-r-fitcBSA/PEG pronouncedly alleviated the initial burst release for higher protein loading and gave better sustainability compared to that of PCL/fitc bovine serum albumin/ PEG nanofiber, which would provide a basis for further design and optimization of processing conditions to control the nanostructure.
References
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Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
TL;DR: A single cell clonal line which responds reversibly to nerve growth factor (NGF) has been established from a transplantable rat adrenal pheochromocytoma and should be a useful model system for neurobiological and neurochemical studies.
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Direct gene transfer into mouse muscle in vivo.
Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
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Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
TL;DR: The ability of fibronectin to bind cells can be accounted for by the tetrapeptide L-arginyl-glycyl- L-aspartyl-L-serine, a sequence which is part of the cell attachment domain of fibronsectin and present in at least five other proteins.
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New methods of drug delivery.
TL;DR: Conventional forms of drug administration generally rely on pills, eye drops, ointments, and intravenous solutions, but a number of novel drug delivery approaches have been developed, which may revolutionize the way many drugs are delivered.
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A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro
TL;DR: Much of the growth-promoting activity of dialyzed serum is directly or indirectly derived from platelets, which has important implications for the response of arteries to localized injury and provides a key to further understanding of the role of factors derived from blood serum in promoting cell proliferation in vitro.