Book ChapterDOI
Mechanical Properties of Bilayer Lipid Membranes and Protein–Lipid Interactions
Reads0
Chats0
TLDR
It is shown that proteins can affect the ordering of the lipid bilayer on substantially larger distance in comparison with that of annular lipids surrounding of the macromolecule.Abstract:
Mechanical properties of the lipid bilayers play a crucial role in maintaining the membrane stability, the shape of the cell, in functioning of the protein molecules and are responsible for protein–lipid interactions. Due to structural inhomogeneity, the membrane is characterized by anisotropy of the mechanical properties. Therefore, description of the mechanical properties of the membrane requires the study of membrane deformation in different directions. This chapter reviews current achievements in understanding the membrane mechanics and its role in explanation of the mechanisms of protein–lipid interactions. Several examples of the effect of short peptides and large integral proteins on the mechanical properties of the membrane are presented. We have shown that proteins can affect the ordering of the lipid bilayer on substantially larger distance in comparison with that of annular lipids surrounding of the macromolecule.read more
Citations
More filters
Journal ArticleDOI
Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.
Melanie P. Muller,Melanie P. Muller,Tao Jiang,Chang Sun,Muyun Lihan,Shashank Pant,Paween Mahinthichaichan,Anda Trifan,Emad Tajkhorshid +8 more
TL;DR: A broad survey of MD simulations focusing on exploring lipid-protein interactions and characterizing lipid-modulated protein structure and dynamics that have been successful in providing novel insight into the mechanism of membrane protein function is provided.
Journal ArticleDOI
Dendrimers complexed with HIV-1 peptides interact with liposomes and lipid monolayers.
Maksim Ionov,Karol Ciepluch,Zuzana Garaiova,Sophie Melikishvili,Sylwia Michlewska,Łucja Balcerzak,Sława Glińska,Katarzyna Milowska,Rafael Gomez-Ramirez,Francisco Javier de la Mata,Dzmitry Shcharbin,Iveta Waczulíková,Maria Bryszewska,Tibor Hianik +13 more
TL;DR: HIV-peptide/dendrimer complexes interact with model lipid membranes depending on their surface charge and Carbosilane dendrimers can be useful as non-viral carriers for delivering HIV- peptides into cells.
Characterization of the volumetric properties of five bioactive peptides, liposomes and their interactions
Maya Desdier,Luis Enrique +1 more
Book ChapterDOI
Effect of Dendrimers and Dendriplexes on Model Lipid Membranes
TL;DR: Experimental work on the effect of different groups of dendrimers on artificial lipid membrane matrices will be reviewed, including studies on the biophysical interaction between lipid membranes and d endrimers that could help in improving the drug delivery applications.
A Ready-to-Use Metal-Supported Bilayer Lipid Membrane Biosensor for the Detection of Phenol in Water.
TL;DR: In this article, a metal-supported bilayer lipid membrane (BLM) biosensor built on tyrosinase to quantitate phenol was presented, which is based on the enzyme-analyte initial association and not the commonly adopted monitoring of the redox cascade reactions.
References
More filters
Journal ArticleDOI
Effect of Chain Length and Unsaturation on Elasticity of Lipid Bilayers
TL;DR: To test this hypothesis, peak-to-peak headgroup thicknesses h(pp) of bilayers were obtained from x-ray diffraction of multibilayer arrays at controlled relative humidities and showed that poly-cis unsaturated chain bilayers are thinner and more flexible than saturated/monounsaturated chain Bilayers.
Journal ArticleDOI
Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution
TL;DR: Comparison with a low-resolution electron density map of the enzyme in the absence of calcium and with biochemical data suggests that large domain movements take place during active transport.
Journal ArticleDOI
Lipid rafts: at a crossroad between cell biology and physics.
TL;DR: The concept of lipid rafts as it has emerged from the study of synthetic membranes with the reality of lateral heterogeneity in biological membranes is compared.
Journal ArticleDOI
Entropy-driven tension and bending elasticity in condensed-fluid membranes.
Evan Evans,W. Rawicz +1 more
TL;DR: Sensitive micropipet methods have been used to measure the relation between tension and the projected surface area in fluid membranes of vesicles and confirm the prediction of equilibrium theory that the projected area should increase logarithmically with tension as shape fluctuations become progressively restricted.