Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release.
Laurence A. Harker,Thomas W. Malpass,Herman E. Branson,Eugene A. Hessel,Sherrill J. Slichter +4 more
Reads0
Chats0
TLDR
It is concluded that cardiopulmonary bypass patients demonstrate abnormal clinical bleeding when there is a persistence of platelet dysfunction manifested as a bleeding time of greater than 20 mm after protamine administration and such bleeding patients with a prolonged bleeding time should receive platelet transfusions.About:
This article is published in Blood.The article was published on 1980-11-01 and is currently open access. It has received 716 citations till now. The article focuses on the topics: Abnormal bleeding & Platelet activation.read more
Citations
More filters
Journal ArticleDOI
The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients
Maria Rosa Costanzo,Anne I. Dipchand,Randall C. Starling,Allen S. Anderson,Michael Chan,Shashank Desai,Savitri Fedson,Patrick W. Fisher,Gonzalo Gonzales-Stawinski,Luigi Martinelli,David C. McGiffin,Jon Smith,David O. Taylor,Bruno Meiser,Steven A. Webber,David A. Baran,Michael P. Carboni,Thomas J. Dengler,David L. Feldman,Maria Frigerio,Abdallah G. Kfoury,Daniel Kim,Jon A. Kobashigawa,Michael A. Shullo,Josef Stehlik,Jeffrey J. Teuteberg,Patricia A. Uber,Andreas Zuckermann,Sharon A. Hunt,Michael Burch,Geetha Bhat,Charles E. Canter,Richard E. Chinnock,Marisa G. Crespo-Leiro,Reynolds M. Delgado,Fabienne Dobbels,Kathleen L. Grady,W. Kao,Jaqueline Lamour,Gareth Parry,Jignesh Patel,Daniela Pini,Jeffrey A. Towbin,Gene Wolfel,Diego H. Delgado,Howard J. Eisen,Lee R. Goldberg,Jeff Hosenpud,Maryl R. Johnson,Anne Keogh,Clive Lewis,John B. O'Connell,Joseph G. Rogers,Heather J. Ross,Stuart D. Russell,Johan Vanhaecke,Amanda W. Rowe +56 more
TL;DR: Institutional Affiliations Chair Costanzo MR: Midwest Heart Foundation, Lombard Illinois, USA Task Force 1 Dipchand A: Hospital for Sick Children, Toronto Ontario, Canada; Starling R: Cleveland Clinic Foundation, Cleveland, Ohio, USA; Starlings R: University of Chicago, Chicago, Illinois,USA; Chan M: university of Alberta, Edmonton, Alberta, Canada ; Desai S: Inova Fairfax Hospital, Fairfax, Virginia, USA.
Journal ArticleDOI
Postoperative Course and Hemodynamic Profile After the Arterial Switch Operation in Neonates and Infants A Comparison of Low-Flow Cardiopulmonary Bypass and Circulatory Arrest
Gil Wernovsky,David Wypij,Richard A. Jonas,John E. Mayer,Frank L. Hanley,Paul R. Hickey,Amy Z. Walsh,Anthony C. Chang,Aldo R. Castaneda,Jane W. Newburger,David L. Wessel +10 more
TL;DR: After heart surgery in neonates and infants, both low-flow bypass and circulatory arrest perfusion strategies have comparable effects on the nonneurological postoperative course and hemodynamic profile.
Journal ArticleDOI
Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry
TL;DR: It is demonstrated that activated platelets can be reliably detected in whole blood using activation-dependent monoclonal antibodies and flow cytometry and may be useful to assess the degree of platelet activation and the efficacy of antiplatelet therapy in clinical disorders.
Journal ArticleDOI
Bleeding Complications Associated With Cardiopulmonary Bypass
TL;DR: The protease inhibitor aprotinin is particularly promising in the reduction of bleeding associated with CPB when given prophylactically and may provide new insights into the mechanism of CPB-induced platelet dysfunction.
Journal ArticleDOI
Exaggerated platelet reactivity in major depression.
Dominique L. Musselman,Aaron Tomer,Amita K. Manatunga,Bettina T. Knight,Maryfrances R. Porter,Suha Kasey,Ulla M. Marzec,Laurence A. Harker,Charles B. Nemeroff +8 more
TL;DR: Depressed patients exhibit enhanced baseline platelet activation and responsiveness in comparison with normal subjects, which may be a mechanism by which depression is a significant risk factor for ischemic heart and cerebrovascular disease and/or mortality after myocardial infarction.
References
More filters
Journal ArticleDOI
The aggregation of blood platelets
G. V. R. Born,M. J. Cross +1 more
TL;DR: A method by which the aggregation of platelets may be followed quantitatively is described, and results obtained with the method are described.
Journal ArticleDOI
Homocystinemia. Vascular injury and arterial thrombosis.
Journal ArticleDOI
Thrombokinetics in man
TL;DR: Platelet production, distribution, and destruction have been quantitated in normal man and in selected patients with platelet disorders and, in most instances, total production as calculated from the megakaryocyte mass agreed with production estimated from platelet turnover.
Journal ArticleDOI
The bleeding time as a screening test for evaluation of platelet function.
TL;DR: The value of the standardized template bleeding time was studied in 100 normal subjects and 136 patients with various disorders and found that with normal platelets the bleeding time in this test is 4.5...