Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction
Reads0
Chats0
TLDR
It is suggested that insights into the mechanisms of epileptogenesis converge at the level of cortical circuit dysfunction, with the hope of preventing epilepsy before seizures emerge.Abstract:
Epilepsy is a prevalent neurological disorder associated with significant morbidity and mortality, but the only available drug therapies target its symptoms rather than the underlying cause The process that links brain injury or other predisposing factors to the subsequent emergence of epilepsy is termed epileptogenesis Substantial research has focused on elucidating the mechanisms of epileptogenesis so as to identify more specific targets for intervention, with the hope of preventing epilepsy before seizures emerge Recent work has yielded important conceptual advances in this field We suggest that such insights into the mechanisms of epileptogenesis converge at the level of cortical circuit dysfunctionread more
Citations
More filters
Journal ArticleDOI
Effects of Postnatal Caffeine Exposure on Absence Epilepsy and Comorbid Depression: Results of a Study in WAG/Rij Rats
TL;DR: Results indicate that postnatal caffeine treatment may decrease the number of seizure and depression-like behaviors in WAG/Rij rats in later life.
Journal ArticleDOI
Identification of epidermal growth factor receptor as an immune-related biomarker in epilepsy using multi-transcriptome data
TL;DR: In this article , a lncRNA-associated competitive endogenous RNA (ceRNA) network was created to explore the immune-related mechanisms in epilepsy disorders, highlight the role of immune cells at the molecular level in epilepsy, and provide therapeutic targets for patients with epilepsy.
Book ChapterDOI
Protocol for Rodent Organotypic Hippocampal Slice Culture Model for Ex Vivo Monitoring of Epileptogenesis
Journal ArticleDOI
Participation of GABA-ergic system in the development of tolerance to action of topiramate and lamotrigine
Journal ArticleDOI
Neuronal activity dynamics in the dentate gyrus during early epileptogenesis
Fredrik Berglind,A Boulot,A. Gonzalez-Ramos,Esbjörn Melin,Antonino Bono,Andreas T. Sørensen,Marco Ledri +6 more
TL;DR: In this article , the authors used a viral vector mediated approach to examine activity of neurons in the dentate gyrus of the hippocampus during early epileptogenesis, and found that indirect inhibition of granule cells by mossy cells through recruitment of local GABAergic interneurons could be an important mechanisms of excitability control during early epilepsy.
References
More filters
mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI
mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI
Genome-Wide Mapping of in Vivo Protein-DNA Interactions
David S. Johnson,Ali Mortazavi,Ali Mortazavi,Richard M. Myers,Richard M. Myers,Barbara J. Wold,Barbara J. Wold +6 more
TL;DR: A large-scale chromatin immunoprecipitation assay based on direct ultrahigh-throughput DNA sequencing was developed, which was then used to map in vivo binding of the neuron-restrictive silencer factor (NRSF; also known as REST) to 1946 locations in the human genome.
Journal ArticleDOI
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Jessica A. Cardin,Marie Carlén,Marie Carlén,Konstantinos Meletis,Konstantinos Meletis,Ulf Knoblich,Feng Zhang,Karl Deisseroth,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai,Christopher I. Moore +11 more
TL;DR: The timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses and provided the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.
Related Papers (5)
ILAE Official Report: A practical clinical definition of epilepsy
Robert S. Fisher,Carlos Acevedo,Alexis Arzimanoglou,Alicia Bogacz,J. Helen Cross,Christian E. Elger,Jerome Engel,Lars Forsgren,Jacqueline A. French,Mike Glynn,Dale C. Hesdorffer,Byung In Lee,Gary W. Mathern,Solomon L. Moshé,Emilio Perucca,Ingrid E. Scheffer,Torbjörn Tomson,Masako Watanabe,Samuel Wiebe +18 more