Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction
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TLDR
It is suggested that insights into the mechanisms of epileptogenesis converge at the level of cortical circuit dysfunction, with the hope of preventing epilepsy before seizures emerge.Abstract:
Epilepsy is a prevalent neurological disorder associated with significant morbidity and mortality, but the only available drug therapies target its symptoms rather than the underlying cause The process that links brain injury or other predisposing factors to the subsequent emergence of epilepsy is termed epileptogenesis Substantial research has focused on elucidating the mechanisms of epileptogenesis so as to identify more specific targets for intervention, with the hope of preventing epilepsy before seizures emerge Recent work has yielded important conceptual advances in this field We suggest that such insights into the mechanisms of epileptogenesis converge at the level of cortical circuit dysfunctionread more
Citations
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Journal ArticleDOI
Microglial contributions to aberrant neurogenesis and pathophysiology of epilepsy.
Tanya R. Victor,Stella E. Tsirka +1 more
TL;DR: The role of microglia post-seizure is still limited and may be pivotal in recognizing new therapeutic targets for seizure intervention, and insights into changes in neurogenesis and synaptic pruning are discovered in both health and disease.
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Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity.
Meng Yang,Ezgi Ozturk,Michael R. Salzberg,Michael R. Salzberg,Sandra Rees,Margaret J. Morris,Terence J. O'Brien,Nigel C. Jones +7 more
TL;DR: The hypothesis that environmental enrichment (EE) confers antiepileptogenic, psychoprotective, and neuroprotective effects in the amygdala kindling model of MTLE is tested and potential neurobiologic mechanisms are explored.
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(+)-Dehydrofukinone modulates membrane potential and delays seizure onset by GABAa receptor-mediated mechanism in mice.
Quelen Iane Garlet,Luana da Costa Pires,Laura Hautrive Milanesi,Joseane Righes Marafiga,Bernardo Baldisserotto,Carlos Fernando Mello,Berta Maria Heinzmann +6 more
TL;DR: The data indicate that DHF has anticonvulsant properties and the molecular target underlying this effect is likely to be the facilitation of GABAergic neuronal inhibition.
Journal ArticleDOI
Noise amplification precedes extreme epileptic events on human EEG
Oleg E. Karpov,Vadim V. Grubov,Vladimir A. Maksimenko,Nikita Utaschev,Viachaslav E. Semerikov,Denis A. Andrikov,Alexander E. Hramov +6 more
TL;DR: In this paper, the authors demonstrate that the time series of electroencephalogram (EEG) spectral power in a frequency band of 1-5 Hz obeys a heavy-tailed distribution, confirming the presence of extreme events.
Journal ArticleDOI
Chronic fluoxetine treatment accelerates kindling epileptogenesis in mice independently of 5-HT2A receptors
Crystal Li,Juliana de Castro e Silva,Ezgi Ozturk,Ezgi Ozturk,Ezgi Ozturk,Gabriella Dezsi,Gabriella Dezsi,Gabriella Dezsi,Terence J. O'Brien,Terence J. O'Brien,Terence J. O'Brien,Thibault Renoir,Nigel C. Jones,Nigel C. Jones,Nigel C. Jones +14 more
TL;DR: It is concluded that treatment with fluoxetine promotes epileptogenesis in mice, but this effect is not mediated by 5‐HT2A receptors, which suggests that antidepressants may accelerate the onset of acquired epilepsy in patients who have experienced epileptogenic cerebral insults.
References
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