Journal ArticleDOI
Membrane deformation of unfixed erythrocytes in air with time lapse investigated by tapping mode atomic force microscopy.
Yong Chen,Jiye Cai +1 more
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TLDR
By successively investigating erythrocytes exposed in air on mica for 5 days using tapping mode atomic force microscopy (TM-AFM), the efficacy of AFM is demonstrated as a potentially powerful analytical tool in forensic science.About:
This article is published in Micron.The article was published on 2006-06-01. It has received 38 citations till now.read more
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Journal ArticleDOI
Age determination of blood spots in forensic medicine by force spectroscopy.
Stefan Strasser,Albert Zink,Gerald Kada,Peter Hinterdorfer,Oliver Peschel,Wolfgang M. Heckl,Wolfgang M. Heckl,Andreas G. Nerlich,Stefan Thalhammer +8 more
TL;DR: AFM is used for high-resolution imaging of erythrocytes in a blood sample and the detection of elasticity changes on a nanometer scale and the elasticity pattern showed a decrease over time, which are most probably influenced by the alteration of the blood spot during the drying and coagulation process.
Journal ArticleDOI
Time-dependent surface adhesive force and morphology of RBC measured by AFM
TL;DR: The AFM detections on the time-dependent, substrate type- dependent, environment (temperature/humidity)-dependent changes in morphology and surface viscoelasticity of RBC imply a potential application of AFM in forensic medicine or investigations, e.g., estimating age of bloodstain or death time.
Journal ArticleDOI
In the pursuit of the holy grail of forensic science – Spectroscopic studies on the estimation of time since deposition of bloodstains
Grzegorz Zadora,Alicja Menżyk +1 more
TL;DR: A critical review of recently developed methods for bloodstain dating, with a particular emphasis on spectroscopy-based approaches is provided, highlighting impediments to applying established procedures in routine forensic practice and perspectives to improve the future developments.
Journal ArticleDOI
Morphological changes in textile fibres exposed to environmental stresses: Atomic force microscopic examination
TL;DR: This study confirmed that the AFM could become a very powerful tool in forensic examination of textile fibres to provide significant fibre evidence due to its capability of distinguishing between different environmental exposures or forced damages to fibres.
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Forensic Applications of Nanotechnology
TL;DR: Nanotechnology has a great influence on modern technology, just like the development of DNA profiling on biotechnology in the past 50 years as mentioned in this paper, because of applying knowledge and techniques from natural science, forensic science aims to identify, individualize and evaluate evidence.
References
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Journal ArticleDOI
Scanning Probe Evolution in Biology
J. K. H. Hörber,Mervyn J Miles +1 more
TL;DR: Instruments with increased imaging rates, lower probe-specimen force interactions, and probe configurations not constrained to planar surfaces are being developed, with the goal of imaging processes at the single-molecule level—not only at surfaces but also within three-dimensional volumes—in real time.
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An overview of the biophysical applications of atomic force microscopy.
TL;DR: AFM is progressively becoming a usual benchtop technique and overcomes materials science applications, showing that 17 years after its invention, AFM has completely crossed the limits of its traditional areas of application.
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Structure of the Erythrocyte Membrane Skeleton as Observed by Atomic Force Microscopy
TL;DR: It was found that freeze-drying (freezing by rapid immersion in a cryogen) of unfixed specimens was a fast and simple way to obtain consistently good results for observation without removing the membrane or extending the membrane skeleton.
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Recent progress in the application of atomic force microscopy imaging and force spectroscopy to microbiology.
TL;DR: Rapid advances have been made using atomic force microscopy to visualize the surface structure of two-dimensional bacterial protein crystals, biofilms and individual cells in physiological conditions and in using force spectroscopy to measure biomolecular interactions and physical properties of microbial surfaces.
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Atomic force microscopy imaging and pulling of nucleic acids.
TL;DR: Highlights of force spectroscopy or pulling of nucleic acids include the use of DNA as a programmable force sensor, and the analysis of RNA flexibility and drug binding to DNA.