Membrane Elasticity in Giant Vesicles with Fluid Phase Coexistence
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TLDR
The observations of experimental vesicle geometries being modulated by Gaussian curvature moduli differences confirm the prediction by the theory of Juelicher and Lipowsky that this geometry of giant unilamellar vesicles with coexisting liquid-disordered and liquid-ordered phases is dominated by the Gauss modulus.About:
This article is published in Biophysical Journal.The article was published on 2005-08-01 and is currently open access. It has received 302 citations till now. The article focuses on the topics: Phase (matter) & Vesicle.read more
Citations
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Journal ArticleDOI
Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles
Tobias Baumgart,Adam T. Hammond,Prabuddha Sengupta,Samuel T. Hess,David Holowka,Barbara Baird,Watt W. Webb +6 more
TL;DR: It is demonstrated that giant plasma membrane vesicles (GPMVs) or blebs formed from the plasma membranes of cultured mammalian cells can also segregate into micrometer-scale fluid phase domains, and GPMVs now provide an effective approach to characterize biological membrane heterogeneities.
Journal ArticleDOI
Effect of line tension on the lateral organization of lipid membranes
TL;DR: The results revealed a linear increase of the temperature of domain formation and domain growth rate with line tension, and domain budding was shown to depend on height mismatch, which contribute significantly to knowledge of the physical-chemical parameters that control membrane organization.
Journal ArticleDOI
Thermodynamics and Mechanics of Membrane Curvature Generation and Sensing by Proteins and Lipids
TL;DR: The present review first provides an overview of important classes of membrane proteins for which function is coupled to membrane curvature, and surveys several mechanisms that are assumed to underlie membranes curvature sensing and generation.
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Sorting of Lipids and Proteins in Membrane Curvature Gradients
Aiwei Tian,Tobias Baumgart +1 more
TL;DR: It is concluded that lipid cooperativity is required to enable efficient sorting in intracellular lipid sorting, contrary to frequent assumptions, and in the framework of statistical mechanical lattice models that show that entropy dominates lipid distribution in the absence of strongly preferential lateral intermolecular interactions.
Journal ArticleDOI
Fluid lipid membranes: From differential geometry to curvature stresses
TL;DR: This review provides a comprehensive introduction into these concepts without assuming the reader's familiarity with differential geometry, and concludes with four more sophisticated applications: boundary conditions for adhering membranes, corrections to the classical micropipette aspiration equation, membrane buckling, and membrane mediated interactions.
References
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Book
Data Reduction and Error Analysis for the Physical Sciences
TL;DR: In this paper, Monte Carlo techniques are used to fit dependent and independent variables least squares fit to a polynomial least-squares fit to an arbitrary function fitting composite peaks direct application of the maximum likelihood.
Journal ArticleDOI
Data Reduction and Error Analysis for the Physical Sciences.
TL;DR: Numerical methods matrices graphs and tables histograms and graphs computer routines in Pascal and Monte Carlo techniques dependent and independent variables least-squares fit to a polynomial least-square fit to an arbitrary function fitting composite peaks direct application of the maximum likelihood.
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Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
Journal ArticleDOI
Elastic Properties of Lipid Bilayers: Theory and Possible Experiments
TL;DR: A theory of the elasticity of lipid bilayers is proposed and it is argued that in the case of vesicles (= closed bilayer films) the only elasticity controlling nonspherical shapes is that of curvature.
Book
Differential geometry of curves and surfaces
TL;DR: This paper presents a meta-geometry of Surfaces: Isometrics Conformal Maps, which describes how the model derived from the Gauss Map changed over time to reflect the role of curvature in the model construction.
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