Journal ArticleDOI
Membrane fusion: a structural perspective on the interplay of lipids and proteins
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TLDR
These structures may be combined with new knowledge on the fusion of pure lipid bilayer membranes in an attempt to begin to piece together the complex puzzle of how biological membrane fusion machines operate on membranes.About:
This article is published in Current Opinion in Structural Biology.The article was published on 2003-08-01. It has received 183 citations till now. The article focuses on the topics: Peripheral membrane protein & Integral membrane protein.read more
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Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
Frits Kamp,Frits Kamp,Nicole Exner,Nicole Exner,Anne Kathrin Lutz,Nora Wender,Jan Hegermann,Bettina Brunner,Bettina Brunner,Brigitte Nuscher,Brigitte Nuscher,Tim Bartels,Armin Giese,Klaus Beyer,Klaus Beyer,Stefan Eimer,Konstanze F. Winklhofer,Christian Haass,Christian Haass +18 more
TL;DR: It is demonstrated with in vitro vesicle fusion experiments that αS has an inhibitory function on membrane fusion and mitochondrial fragmentation induced by expression of αS is rescued by coexpression of PINK1, parkin or DJ‐1 but not the PD‐associated mutations Pink1 G309D and parkin Δ1–79 or byDJ‐1 C106A.
Journal ArticleDOI
Membrane Hemifusion: Crossing a Chasm in Two Leaps
TL;DR: During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore, called hemifusion.
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Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: Insights from vesicle recycling in nerve terminals
Markus R. Wenk,Pietro De Camilli +1 more
TL;DR: Powerful methods for the detection of lipids are rapidly advancing this field, thus complementing the broad range of information about biological systems that can be obtained from genomic and proteomic approaches.
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Biological and synthetic membranes: What can be learned from a coarse-grained description?
TL;DR: Applications of coarse-grained models to changes of the membrane topology are illustrated with studies of membrane fusion utilizing simulations and self-consistent field theory.
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Dynamin: Functional Design of a Membrane Fission Catalyst
TL;DR: A two-stage model for dynamin-catalyzed fission is proposed, where dynamin's mechanochemical activities induce localized curvature stress and position its lipid-interacting pleckstrin homology domains to create a catalytic center that guides lipid remodeling through hemifission intermediates to drive membrane fission.
References
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Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
John J. Skehel,Don C. Wiley +1 more
TL;DR: Comparisons to the soluble N-ethyl-maleimide-sensitive factor attachment protein receptor (SNARE) protein complex of vesicle fusion suggests that these molecules are all in the fusion-activated conformation and that the juxtaposition of the membrane anchor and fusion peptide, a recurring feature, is involved in the fused mechanism.
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Structure of lipid bilayers
TL;DR: The uncertainty in structural results for lipid bilayers is being reduced and best current values are provided for bilayers of five lipids.
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Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
TL;DR: The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and a globular region of antiparallel β-sheet is positioned on top of this stem.
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Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
TL;DR: The X-ray crystal structure of a core synaptic fusion complex containing syntaxin-1A, synaptobrevin-II and SNAP-25B reveals a highly twisted and parallel four-helix bundle that differs from the bundles described for the haemagglutinin and HIV/SIV gp41 membrane-fusion proteins.