Metabolic Effects of Krill Oil are Essentially Similar to Those of Fish Oil but at Lower Dose of EPA and DHA, in Healthy Volunteers
Stine Marie Ulven,Bente Kirkhus,Amandine Lamglait,Samar Basu,Elisabeth Elind,Trond Haider,Kjetil Berge,Hogne Vik,Jan I. Pedersen +8 more
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TLDR
Krill oil and fish oil represent comparable dietary sources of n-3 PUFAs, even if the EPA + DHA dose in the krill oil was 62.8% of that in the fish oil, and no statistically significant differences in changes in any of the serum lipids or the markers of oxidative stress and inflammation between the study groups were observed.Abstract:
The purpose of the present study is to investigate the effects of krill oil and fish oil on serum lipids and markers of oxidative stress and inflammation and to evaluate if different molecular forms, triacylglycerol and phospholipids, of omega-3 polyunsaturated fatty acids (PUFAs) influence the plasma level of EPA and DHA differently. One hundred thirteen subjects with normal or slightly elevated total blood cholesterol and/or triglyceride levels were randomized into three groups and given either six capsules of krill oil (N = 36; 3.0 g/day, EPA + DHA = 543 mg) or three capsules of fish oil (N = 40; 1.8 g/day, EPA + DHA = 864 mg) daily for 7 weeks. A third group did not receive any supplementation and served as controls (N = 37). A significant increase in plasma EPA, DHA, and DPA was observed in the subjects supplemented with n-3 PUFAs as compared with the controls, but there were no significant differences in the changes in any of the n-3 PUFAs between the fish oil and the krill oil groups. No statistically significant differences in changes in any of the serum lipids or the markers of oxidative stress and inflammation between the study groups were observed. Krill oil and fish oil thus represent comparable dietary sources of n-3 PUFAs, even if the EPA + DHA dose in the krill oil was 62.8% of that in the fish oil.read more
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Functions of plasmalogen lipids in health and disease.
Nancy Braverman,Ann B. Moser +1 more
TL;DR: Current knowledge of plasmalogen biology in health and disease is presented and secondary plAsmalogen deficiencies associated with more common disorders are revealed.
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Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance - A review.
TL;DR: Major sources, intake, and global consumption of n-3 and n-6 PUFAs are summarized and their metabolism to biosynthesize long-chain PUF as and eicosanoids and their roles in brain metabolism, cardiovascular disease, obesity, cancer, and bone health are discussed.
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Omega-3 fatty acids and metabolic syndrome: Effects and emerging mechanisms of action
TL;DR: Evidence for pharmacological responses and the mechanism of action of each of the n-3 fatty acid trio will be discussed for the major risk factors of metabolic syndrome, especially adiposity, dyslipidemia, insulin resistance and diabetes, hypertension, oxidative stress, and inflammation.
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Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel.
Arrigo F G Cicero,Alessandro Colletti,Gani Bajraktari,Olivier Descamps,Dragan M. Djuric,Marat V. Ezhov,Zlatko Fras,Niki Katsiki,Michel Langlois,Gustavs Latkovskis,Demosthenes B. Panagiotakos,György Paragh,Dimitri P. Mikhailidis,Olena Mitchenko,Bernhard Paulweber,Daniel Pella,Christos Pitsavos,Željko Reiner,Kausik K. Ray,Manfredi Rizzo,Amirhossein Sahebkar,Maria-Corina Serban,Laurence S. Sperling,Peter P. Toth,Dragos Vinereanu,Michal Vrablík,Nathan D. Wong,Maciej Banach +27 more
TL;DR: The purpose of this position paper is to provide consensus-based recommendations for the optimal use of lipid-lowering nutraceuticals to manage dyslipidemia in patients who are still not on statin therapy, patients who have not achieved lipid goals, and patients with statin intolerance.
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Bioavailability of long-chain omega-3 fatty acids.
TL;DR: There is a need to systematically investigate the bioavailability of omega-3 fatty acids formulations, which might be a key to designing more effective studies in the future.
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