Journal ArticleDOI
Omega-3 fatty acids and metabolic syndrome: Effects and emerging mechanisms of action
TLDR
Evidence for pharmacological responses and the mechanism of action of each of the n-3 fatty acid trio will be discussed for the major risk factors of metabolic syndrome, especially adiposity, dyslipidemia, insulin resistance and diabetes, hypertension, oxidative stress, and inflammation.About:
This article is published in Progress in Lipid Research.The article was published on 2011-10-01. It has received 368 citations till now. The article focuses on the topics: Fatty acid & Docosahexaenoic acid.read more
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Journal ArticleDOI
Omega-3 Long-Chain Polyunsaturated Fatty Acids, EPA and DHA: Bridging the Gap between Supply and Demand.
TL;DR: All the new sources have potentially important roles to play in increasing the supply of n-3 LC-PUFA so that they are available more widely and in higher concentrations providing more options and opportunities for human consumers to obtain sufficient EPA and DHA to support more healthy, balanced diets.
Journal ArticleDOI
Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation
Pablo Perez-Martinez,Dimitri P. Mikhailidis,Vasilios G. Athyros,Mònica Bulló,Patrick Couture,María Isabel Covas,María Isabel Covas,Lawrence de Koning,Javier Delgado-Lista,Andrés Díaz-López,Christian A. Drevon,Ramon Estruch,Katherine Esposito,Montserrat Fitó,Montserrat Fitó,Marta Garaulet,Dario Giugliano,Antonio Garcia-Rios,Niki Katsiki,Genovefa Kolovou,Benoît Lamarche,Maria Ida Maiorino,Guillermo Mena-Sánchez,Araceli Muñoz-Garach,Dragana Nikolic,Jose M. Ordovas,Jose M. Ordovas,Jose M. Ordovas,Francisco Pérez-Jiménez,Manfredi Rizzo,Jordi Salas-Salvadó,Helmut Schröder,Francisco J. Tinahones,Rafael de la Torre,Rafael de la Torre,Ben van Ommen,Suzan Wopereis,Emilio Ros,Emilio Ros,Jose Lopez-Miranda +39 more
TL;DR: A healthy lifestyle is critical to prevent or delay the onset of MetS in susceptible individuals and to prevent cardiovascular disease and type 2 diabetes in those with existing MetS.
Journal ArticleDOI
α-Linolenic acid: nutraceutical, pharmacological and toxicological evaluation.
TL;DR: It may be concluded that ALA may be beneficial as a nutraceutical/pharmaceutical candidate and is safe for use as a food ingredient.
Journal ArticleDOI
Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context.
TL;DR: This review focuses on lifestyle changes, especially dietary habits, that are at the basis of chronic systemic low grade inflammation, insulin resistance and Western diseases, and the disturbance of the authors' inflammatory/anti-inflammatory balance is illustrated by dietary fatty acids and antioxidants.
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Protective Effects of the Mediterranean Diet on Type 2 Diabetes and Metabolic Syndrome
Jordi Salas-Salvadó,Jordi Salas-Salvadó,Marta Guasch-Ferré,Marta Guasch-Ferré,Chih-Hao Lee,Ramon Estruch,Ramon Estruch,Clary B. Clish,Emilio Ros,Emilio Ros +9 more
TL;DR: Abundant epidemiologic and clinical trial evidence supports the role of the MedDiet on the prevention and management of T2DM and MetS.
References
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Journal ArticleDOI
Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
K. G. M. M. Alberti,Robert H. Eckel,Scott M. Grundy,Paul Zimmet,James I. Cleeman,Karen A. Donato,Jean Charles Fruchart,W. Philip T. James,Catherine M. Loria,Sidney C. Smith +9 more
TL;DR: It was agreed that there should not be an obligatory component, but that waist measurement would continue to be a useful preliminary screening tool, and a single set of cut points would be used for all components except waist circumference, for which further work is required.
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A central role for JNK in obesity and insulin resistance
Jiro Hirosumi,Gurol Tuncman,Lufen Chang,Cem Z. Görgün,K. Teoman Uysal,Kazuhisa Maeda,Michael Karin,Gökhan S. Hotamisligil +7 more
TL;DR: It is shown that JNK activity is abnormally elevated in obesity and an absence of JNK1 results in decreased adiposity, significantly improved insulin sensitivity and enhanced insulin receptor signalling capacity in two different models of mouse obesity.
Journal ArticleDOI
Resolving inflammation : dual anti-inflammatory and pro-resolution lipid mediators
TL;DR: New cellular and molecular mechanisms for the resolution of inflammation are presented, revealing key roles for eicosanoids, such as lipoxins, and recently discovered families of endogenous chemical mediators, termed resolvins and protectins, which have anti-inflammatory and pro-resolution properties.
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Mechanisms linking obesity with cardiovascular disease
TL;DR: The underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health are beginning to be understood.
Journal ArticleDOI
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
TL;DR: At sufficiently high intakes, long-chain n-3 polyunsaturated fatty acids (PUFAs), as found in oily fish and fish oils, decrease the production of inflammatory eicosanoids, cytokines, and reactive oxygen species and the expression of adhesion molecules, and are potentially potent antiinflammatory agents.