Journal ArticleDOI
Metabolism and atherogenic disease association of lysophosphatidylcholine
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TLDR
The detection of LPC by mass spectrometry is outlined which is currently the best method for accurate and simultaneous analysis of each individual LPC species and the pathophysiological implication is revealed which makes it an interesting target for biomarker and drug development regarding atherosclerosis and cardiovascular disorders.About:
This article is published in Atherosclerosis.The article was published on 2010-01-01. It has received 286 citations till now.read more
Citations
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Journal ArticleDOI
An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases.
TL;DR: Understanding enzyme kinetics and LPC metabolism may help identify novel therapeutic targets in LPC-associated diseases, and address the coordination of these enzymes and the derangement that may disrupt LPC homeostasis, leading to metabolic disorders.
Journal ArticleDOI
Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification
Huichu Li,Jing Cai,Renjie Chen,Zhuohui Zhao,Zhekang Ying,Lin Wang,Jianmin Chen,Ke Hao,Patrick L. Kinney,Honglei Chen,Haidong Kan +10 more
TL;DR: It is suggested that higher PM may induce metabolic alterations that are consistent with activations of the hypothalamus-pituitary-adrenal and sympathetic- adrenal-medullary axes, adding potential mechanistic insights into the adverse health outcomes associated with PM.
Journal ArticleDOI
Metabolomic Analysis of Livers and Serum from High-Fat Diet Induced Obese Mice
Hyun-Jin Kim,Jin Hee Kim,Siwon Noh,Haeng Jeon Hur,Mi Jeong Sung,Jin-Taek Hwang,Jae Ho Park,Hye Jeong Yang,Myung-Sunny Kim,Dae Young Kwon,Suk Hoo Yoon +10 more
TL;DR: A high-fat diet increased lipid metabolites but decreased lipid metabolism intermediates and the NAD/NADH ratio, indicating that abnormal lipid and energy metabolism induced by a high- fat diet resulted in fat accumulation via decreased β-oxidation.
Journal ArticleDOI
Plasma lipid profiling in a large population-based cohort
Jacquelyn M. Weir,Gerard Wong,Christopher K. Barlow,Melissa A. Greeve,Adam Kowalczyk,Laura Almasy,Anthony G. Comuzzie,Michael C. Mahaney,Jeremy B. M. Jowett,Jonathan E. Shaw,Joanne E. Curran,John Blangero,Peter J. Meikle +12 more
TL;DR: In this paper, the authors performed plasma lipid profiling using liquid chromatography electrospray ionization tandem mass spectrometry on a population cohort of more than 1,000 individuals and identified statistically significant associations of lipid classes, subclasses, and individual lipid species with anthropometric and physiological measures.
Journal ArticleDOI
An update of MALDI-TOF mass spectrometry in lipid research.
TL;DR: MALDI MS can be very easily combined with thin-layer chromatography (TLC) allowing the spatially-resolved screening of the entire TLC plate and the detection of lipids with a higher sensitivity than common staining protocols.
References
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Journal ArticleDOI
Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids
TL;DR: A complex process in which endothelial cells modify LDL by mechanisms involving generation of free radicals and action of phospholipase (s) is suggested, including degradation of phosphatidylcholine.
Book
Biochemistry of lipids, lipoproteins, and membranes
Dennis E. Vance,Jean E. Vance +1 more
TL;DR: This chapter discusses the physical properties and functional Roles of Lipids in Membranes, as well as the Dynamics of Lipoprotein Transport in the Circulatory System.
Journal ArticleDOI
Minimally modified low density lipoprotein stimulates monocyte endothelial interactions
Judith A. Berliner,Mary C. Territo,Alex Sevanian,S Ramin,J A Kim,B Bamshad,M Esterson,A M Fogelman +7 more
TL;DR: It is concluded that exposure of EC to sublethal levels of MM-LDL enhances monocyte endothelial interactions and induces resistance to the toxic effects of MM -LDL.
Journal ArticleDOI
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
Makiko Umezu-Goto,Yasuhiro Kishi,Akitsu Taira,Kotaro Hama,Naoshi Dohmae,Koji Takio,Takao Yamori,Gordon B. Mills,Keizo Inoue,Keizo Inoue,Junken Aoki,Hiroyuki Arai +11 more
TL;DR: The demonstration that ATX and lysoPLD are identical suggests that autocrine or paracrine production of LPA contributes to tumor cell motility, survival, and proliferation, and provides potential novel targets for therapy of pathophysiological states including cancer.
Journal ArticleDOI
Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal
Kirsten Lauber,Erwin Bohn,Stefan M Kröber,Yi Jin Xiao,Sibylle G. Blumenthal,Ralph K. Lindemann,P. Marini,Carolin A. Wiedig,Anke Zobywalski,Shairaz Baksh,Yan Xu,Ingo B. Autenrieth,Klaus Schulze-Osthoff,Claus Belka,Gernot Stuhler,Sebastian Wesselborg +15 more
TL;DR: Evidence is presented that apoptotic cells secrete chemotactic factor(s) that stimulate the attraction of monocytic cells and primary macrophages and that lysophosphatidylcholine was released from apoptotic Cells due to the caspase-3 mediated activation of the calcium-independent phospholipase A(2).