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Open AccessJournal ArticleDOI

Plasma lipid profiling in a large population-based cohort

Jacquelyn M. Weir, +12 more
- 01 Oct 2013 - 
- Vol. 54, Iss: 10, pp 2898-2908
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TLDR
In this paper, the authors performed plasma lipid profiling using liquid chromatography electrospray ionization tandem mass spectrometry on a population cohort of more than 1,000 individuals and identified statistically significant associations of lipid classes, subclasses, and individual lipid species with anthropometric and physiological measures.
About: 
This article is published in Journal of Lipid Research.The article was published on 2013-10-01 and is currently open access. It has received 310 citations till now. The article focuses on the topics: Lipidomics.

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Citations
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Journal ArticleDOI

Toward Merging Untargeted and Targeted Methods in Mass Spectrometry-Based Metabolomics and Lipidomics.

Tomas Cajka, +2 more
- 05 Jan 2016 - 
TL;DR: This work focuses on the application of mass spectrometry to the treatment of metabolomics and Lipidomics with a focus on the characterization of the role of phosphorous in the biosynthetic pathway.
Journal ArticleDOI

Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry

Tomas Cajka, +1 more
- 01 Oct 2014 - 
TL;DR: This review focuses on state of the art in LC-MS-based lipidomics, covering all the steps of global lipidomic profiling, and concludes that phospholipids followed by sphingomyelins, di- and tri-acylglycerols, and ceramides were the most frequently targeted lipid species.
Journal ArticleDOI

Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences

Kui Yang, +2 more
- 01 Nov 2016 - 
TL;DR: This review provides a timely update on very recent applications of lipidomics in health and disease and compares mass spectrometry-based techniques for analysis of lipids.
Journal ArticleDOI

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

Peter J. Meikle, +1 more
- 01 Feb 2017 - 
TL;DR: What is currently known about phospholipid and sphingolipids metabolism in the setting of obesity and how metabolic pathways are being modulated for therapeutic effect are examined.
Journal ArticleDOI

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

Graeme I. Lancaster, +30 more
- 01 May 2018 - 
TL;DR: It is shown that TLR4-dependent priming alters cellular metabolism, gene expression, lipid metabolic pathways, and membrane lipid composition, changes that are necessary for lcSFA-induced inflammation.
References
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Journal ArticleDOI

Controlling the false discovery rate: a practical and powerful approach to multiple testing

Yoav Benjamini, +1 more
- 01 Jan 1995 - 
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI

A simple method for the isolation and purification of total lipides from animal tissues.

Jordi Folch, +2 more
- 01 May 1957 - 
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
Journal ArticleDOI

Lipidomics reveals a remarkable diversity of lipids in human plasma

Oswald Quehenberger, +23 more
- 01 Nov 2010 - 
TL;DR: The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids and to quantitatively assessed the levels of over 500 distinct molecular species distributed among the main lipid categories.
Journal ArticleDOI

Systemic oxidative stress in asthma, COPD, and smokers.

Irfan Rahman, +3 more
- 01 Oct 1996 - 
TL;DR: Smoking, acute exacerbations of COPD, and asthma are associated with a marked oxidant/ant antioxidant imbalance in the blood, associated with evidence of increased oxidative stress, and the decreased antioxidant capacity in plasma may result from different mechanisms in these conditions.
Journal ArticleDOI

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism

William L. Holland, +1 more
- 15 Jan 2008 - 
TL;DR: The role of ceramide and other sphingolipid metabolites in insulin resistance, beta-cell failure, cardiomyopathy, and vascular dysfunction is reviewed, focusing on in vivo studies that identify enzymes controlling sphingoipid metabolism as therapeutic targets for combating metabolic disease.
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Lipidomics reveals a remarkable diversity of lipids in human plasma

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Lipidomics Profiling and Risk of Cardiovascular Disease in the Prospective Population-based Bruneck Study

Christin Stegemann, +13 more
- 06 May 2014 - 

Controlling the false discovery rate: a practical and powerful approach to multiple testing

Yoav Benjamini, +1 more
- 01 Jan 1995 - 

A simple method for the isolation and purification of total lipides from animal tissues.

Jordi Folch, +2 more
- 01 May 1957 - 

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans

Eugene P. Rhee, +23 more
- 01 Apr 2011 -