Journal ArticleDOI
Metabolism of 4-Hydroxynonenal by Rat Kupffer Cells☆
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TLDR
The metabolic ability of Kupffer cells to detoxify 4-HNE through oxidative (aldehyde dehydrogenase; ALDH), reductive (alcohol dehydrogen enzyme; ADH), and conjugative (glutathione S-transferase; GST) pathways was characterized and suggested that Kupfer cells are potentially vulnerable to the increased concentrations of 4- HNE occurring during oxidative stress.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 2001-05-01. It has received 52 citations till now. The article focuses on the topics: Liver cell & 4-Hydroxynonenal.read more
Citations
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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
Jay D. Horton,Nila Shah,Janet A. Warrington,Norma N. Anderson,Sahng Wook Park,Michael S. Brown,Joseph L. Goldstein +6 more
TL;DR: Through application of stringent combinatorial criteria, the transgenic/knockout approach allows identification of genes whose activities are likely to be controlled directly by one family of transcription factors, in this case the SREBPs.
Journal ArticleDOI
Cellular glutathione and thiols metabolism.
TL;DR: It is the aim that this commentary will lead the reader to appreciate that studies investigating the signaling for and regulation of thiol metabolism must never be generalized, and that perturbations in any of step ofThioredoxin and glutathione metabolism may have etiological roles in genetically, virally, and environmentally borne pathologies.
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Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.
TL;DR: What is currently known about each member of the human ALDH superfamily, composed of NAD(P)+-dependent enzymes that catalyze aldehyde oxidation, is presented including the pathophysiological significance of these enzymes.
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Glutathione in Defense and Signaling
TL;DR: The elucidation of the signaling for GSH biosynthesis in human bronchial epithelial cells in response to 4‐hydroxynonenal (4HNE), an end product of lipid peroxidation, will be used as an example.
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Kupffer cells in non-alcoholic fatty liver disease: the emerging view.
TL;DR: Altered lipid homeostasis in NAFLD may unfavourably affect TLR4 receptor complex assembly and sorting, interfere with signalling flux redistribution, promote amplification loops, and impair negative regulation including alternative activation of Kupffer cells.
References
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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
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Biologically active products of stimulated liver macrophages (Kupffer cells)
TL;DR: Topological factors seem to influence their final differentiation and to endow each type with particular metabolic and structural features in the body’s defensive machinery.
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Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation: 4-HYDROXY-2-NONENAL IS A POTENTIAL INDUCER OF INTRACELLULAR PEROXIDE PRODUCTION *
TL;DR: The findings that HNE strongly induced intracellular peroxide production, HNE-induced JNK activation was inhibited by pretreatment of the cells with a thiol antioxidant, N-acetylcysteine, and H2O2 significantly activated JNK support the hypothesis that pro-oxidants play a crucial role in the H NE-induced activation of stress signaling pathways.
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Inactivation of Kupffer cells prevents early alcohol-induced liver injury.
TL;DR: It is demonstrated that GdCl3 prevents alcohol‐induced liver injury and suggest strongly that Kupffer cells participate in the early phases of the disease process and might represent a new approach to clinical management of alcohol‐ induced liver injury.
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Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.
Koji Uchida,Earl R. Stadtman +1 more
TL;DR: It is proposed that the carbonyl groups of the HNE-derived Michael addition products may undergo secondary reactions with the amino acid groups of lysine residues to yield inter- and intrasubunit cross-links.