Journal ArticleDOI
Metaphase chromosome structure: Evidence for a radial loop model
M.P.F. Marsden,Ulrich K. Laemmli +1 more
Reads0
Chats0
TLDR
A model in which the nucleoprotein fiber is folded into loops which are arranged in the Chromatid in radial fashion, in such a way that their bases become the central axis of the chromatid is discussed.About:
This article is published in Cell.The article was published on 1979-08-01. It has received 530 citations till now. The article focuses on the topics: Metaphase & Chromatid.read more
Citations
More filters
Journal ArticleDOI
Expression of a β-globin gene is enhanced by remote SV40 DNA sequences
TL;DR: The activation of genes by specific enhancer elements seems to be a widespread mechanism that may be used for the regulation of gene expression and defines a class of DNA elements with a mode of action that has not been heretofore described.
Journal ArticleDOI
Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold
TL;DR: Data are presented for sequence-specific chromatin-loop organization in histone-depleted nuclei from Drosophila melanogaster Kc cells and a family of attachment sites related by hybridization to those of the hsp70 genes was discovered.
Journal ArticleDOI
Organization of the Mitotic Chromosome
Natalia Naumova,Maxim Imakaev,Geoffrey Fudenberg,Geoffrey Fudenberg,Ye Zhan,Bryan R. Lajoie,Leonid A. Mirny,Job Dekker +7 more
TL;DR: Using polymer simulations, it is found that metaphase Hi-C data are inconsistent with classic hierarchical models and are instead best described by a linearly organized longitudinally compressed array of consecutive chromatin loops.
Journal ArticleDOI
Organization and function of the 3D genome.
TL;DR: The insights into chromatin architecture that have been gained through recent technological developments in quantitative biology, genomics and cell and molecular biology approaches are discussed and how these new concepts have been used to address important biological questions in development and disease are explained.
Journal ArticleDOI
Disseminating the Genome: Joining, Resolving, and Separating Sister Chromatids During Mitosis and Meiosis
TL;DR: New research has identified proteins that hold sisters together while they are aligned on the metaphase plate and shed insight into the mechanisms that dissolve sister chromatid cohesion during both mitosis and meiosis.
References
More filters
Journal ArticleDOI
THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY
TL;DR: The stain reported here differs from previous alkaline lead stains in that the chelating agent, citrate, is in sufficient excess to sequester all lead present, and is less likely to contaminate sections.
Journal ArticleDOI
Spheroid Chromatin Units (ν Bodies)
Ada L. Olins,Donald E. Olins +1 more
TL;DR: Linear arrays of spherical chromatin particles about 70 angstroms in diameter have been observed in preparations of isolated eukaryotic nuclei swollen in water, centrifuged onto carbon films, and positively or negatively stained.
Journal ArticleDOI
Structure of chromatin.
TL;DR: The structure of nucleus and linker is described and the path followed by the DNA is described, revealing the arrangement of Histones and their role in theogenesis.
Journal ArticleDOI
The structure of histone-depleted metaphase chromosomes
J. R. Paulson,Ulrich K. Laemmli +1 more
TL;DR: A scaffolding model for metaphase chromosome structure is suggested in which a backbone of nonhistone proteins is responsible for the basic shape of metaphase chromosomes, and the scaffold organizes the DNA into loops along its length.
Journal ArticleDOI
Supercoils in human DNA
Peter R. Cook,I.A. Brazell +1 more
TL;DR: The results are interpreted as showing that human DNA is supercoiled and a model for the structure of the chromosome is suggested.