Journal ArticleDOI
Microbial siderophores: a mini review
TLDR
A major breakthrough is taking place in the understanding of the multifaceted role of siderophores in nature and this mini review is intended to provide a general overview of its role and applications.Abstract:
Iron is one of the major limiting factors and essential nutrients of microbial life. Since in nature it is not readily available in the preferred form, microorganisms produce small high affinity chelating molecules called siderophores for its acquisition. Microorganisms produce a wide variety of siderophores controlled at the molecular level by different genes to accumulate, mobilize and transport iron for metabolism. Siderophores also play a critical role in the expression of virulence and development of biofilms by different microbes. Apart from maintaining microbial life, siderophores can be harnessed for the sustainability of human, animals and plants. With the advent of modern molecular tools, a major breakthrough is taking place in the understanding of the multifaceted role of siderophores in nature. This mini review is intended to provide a general overview on siderophore along with its role and applications.read more
Citations
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Journal ArticleDOI
Iron and cancer: more ore to be mined
Suzy V. Torti,Frank M. Torti +1 more
TL;DR: Targeting iron metabolic pathways may provide new tools for cancer prognosis and therapy and suggest that reprogramming of iron metabolism is a central aspect of tumour cell survival.
Journal ArticleDOI
Mechanisms of action of plant growth promoting bacteria
TL;DR: To realize the objective of worldwide sustainable agriculture, it is essential that the many mechanisms employed by PGPB first be thoroughly understood thereby allowing workers to fully harness the potentials of these microbes.
Journal ArticleDOI
Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options.
Chang-Ro Lee,Jung Hun Lee,Moonhee Park,Kwang Seung Park,Il Kwon Bae,Young Bae Kim,Chang-Jun Cha,Byeong Chul Jeong,Sang Hee Lee +8 more
TL;DR: Current studies on the virulence factors that contribute to A. baumannii pathogenesis are summarized and Mechanisms of antibiotic resistance of this organism, including acquirement of β-lactamases, up-regulation of multidrug efflux pumps, modification of aminoglycosides, permeability defects, and alteration of target sites are discussed.
Journal ArticleDOI
Biological nitrogen fixation in non-legume plants
TL;DR: Improved understanding of the molecular mechanism of BNF outside the legume-rhizobium symbiosis could have important agronomic implications and enable the use of N-fertilizers to be reduced or even avoided.
Journal ArticleDOI
The evolution of genome mining in microbes – a review
TL;DR: Different approaches of mining genomes for secondary metabolites are focused, from detecting biosynthetic genes to resistance based methods and "evo-mining" strategies including a short evaluation of the impact of the development of genome mining methods and tools on the field of natural products and microbial ecology.
References
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Journal ArticleDOI
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TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Journal ArticleDOI
Antibiotic resistance of bacteria in biofilms
TL;DR: The features of biofilm infections are summarized, the emerging mechanisms of resistance are reviewed, and potential therapies are discussed.
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TL;DR: It is submitted that complex cell-cell interactions within prokaryotic communities are an ancient characteristic, the development of which was facilitated by the localization of cells at surfaces, which may have provided the protective niche in which attached cells could create a localized homeostatic environment.
Journal ArticleDOI
Bacterial iron homeostasis
TL;DR: The expression of the iron homeostatic machinery is subject to iron-dependent global control ensuring that iron acquisition, storage and consumption are geared to iron availability and that intracellular levels of free iron do not reach toxic levels.
Journal ArticleDOI
Biological control of soil-borne pathogens by fluorescent pseudomonads
Dieter Haas,Geneviève Défago +1 more
TL;DR: Biocontrol strains of fluorescent pseudomonads produce antifungal antibiotics, elicit induced systemic resistance in the host plant or interfere specifically with fungal pathogenicity factors during root colonization.
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