Journal ArticleDOI
Microparticle formation and its mechanism in single and double emulsion solvent evaporation
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TLDR
This study investigates the mechanism of the solvent elimination from the emulsion droplets and its influence on the particle morphology, encapsulation and release behavior of microparticles in double emulsion formulations.About:
This article is published in Journal of Controlled Release.The article was published on 2004-09-30. It has received 331 citations till now. The article focuses on the topics: Microparticle & Emulsion.read more
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Journal ArticleDOI
Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
TL;DR: This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release.
Journal ArticleDOI
Advances in drug delivery via electrospun and electrosprayed nanomaterials.
TL;DR: This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.
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Nanoparticle–aptamer bioconjugates for cancer targeting
TL;DR: The goal of this review is to summarise the key components that are required for creating effective cancer targeting nanoparticle–aptamer bioconjugates.
Journal ArticleDOI
Strategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: State-of-the-art and challenges.
Farshad Ramazani,Weiluan Chen,C.F. van Nostrum,Gerrit Storm,Fabian Kiessling,Twan Lammers,Wim E. Hennink,Robbert J. Kok +7 more
TL;DR: Novel microencapsulation technologies such as microfluidics, membrane emulsification and other techniques including spray drying and inkjet printing afford production of this type of drug loaded microspheres in a robust and well controlled manner.
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Evaluation of ciprofloxacin-loaded Eudragit® RS100 or RL100/PLGA nanoparticles
TL;DR: In this paper, two non-biodegradable positively charged polymers, Eudragit RS100 and RL100, and the biodegradability polymer poly(lactic-co-glycolic acid) or PLGA were used alone or in combination, with varying ratios.
References
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Journal ArticleDOI
Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
Journal ArticleDOI
A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS.
L Mu,Si-Shen Feng +1 more
TL;DR: Vitamin E TPGS has great advantages for the manufacture of polymeric nanoparticles for controlled release of paclitaxel and other anti-cancer drugs and could be a novel surfactant as a matrix material when blended with other biodegradable polymers.
Journal ArticleDOI
A New Technique to Efficiently Entrap Leuprolide Acetate into Microcapsules of Polylactic Acid or Copoly(Lactic/Glycolic) Acid
TL;DR: The aim of this work was to develop injectable microcapsules containing leuprolide acetate that would deliver that drug at a zero-order rate over a period of about one month, but the release profiles of the drug in vitro were inadequate for controlled release for one month.
Reference BookDOI
Microparticulate systems for the delivery of proteins and vaccines
Smadar Cohen,Howard Bernstein +1 more
TL;DR: Stability of Proteins and Their Delivery from Biodegradable Polymer Microspheres, Steven S. Schwenderman Injectable Biodesgradable Microsphere for Vaccine Delivery, Thomas Kissel and Regina Koneberg Preparation of Microparticulates Using Supercritical Fluids.
Journal ArticleDOI
Protein-loaded poly(dl-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics
TL;DR: In this paper, a water-inoil-in-water (w/o/w) emulsification-solvent evaporation technique was used to entrap bovine serum albumin in sub-5 micron particles of poly(dl -lactide-co-glycolide copolymer) (PLG) using a waterin-oil-IN-water emulsion technique, and the concentration of PVA stabiliser in the external continuous phase was found to affect not only the particle size, size distribution and protein content but also