MicroRNA in intervertebral disc degeneration.
TLDR
Current research enlightenment towards understanding roles of microRNAs in regulating nucleus pulposus cell functions in IDD is summarized, supporting the notion that specific modulation of micro RNAs may represent an attractive approach for management of IDD.Abstract:
Aetiology of intervertebral disc degeneration (IDD) is complex, with genetic, developmental, biochemical and biomechanical factors contributing to the disease process. It is becoming obvious that epigenetic processes influence evolution of IDD as strongly as the genetic background. Deregulated phenotypes of nucleus pulposus cells, including differentiation, migration, proliferation and apoptosis, are involved in all stages of progression of human IDD. Non-coding RNAs, including microRNAs, have recently been recognized as important regulators of gene expression. Research into roles of microRNAs in IDD has been very active over the past 5 years. Our review summarizes current research enlightenment towards understanding roles of microRNAs in regulating nucleus pulposus cell functions in IDD. These exciting findings support the notion that specific modulation of microRNAs may represent an attractive approach for management of IDD.read more
Citations
More filters
Journal ArticleDOI
Long non-coding RNAs in nucleus pulposus cell function and intervertebral disc degeneration
Zheng Li,Xingye Li,Chong Chen,Shugang Li,Jianxiong Shen,Gary Tse,Matthew T. V. Chan,William K.K. Wu +7 more
TL;DR: This review summarizes current research regarding the roles of deregulated lncRNAs in modulating nucleus pulposus cell functions in IDD and suggests that specific modulation of lnc RNAs or their downstream signalling pathways might be an attractive approach for developing novel therapeutics for IDD.
Journal ArticleDOI
Mechanisms of endogenous repair failure during intervertebral disc degeneration
TL;DR: The current research situation and progress of the mechanisms through which IVD stem/progenitor cells failed to repair IVD tissues during IVD degeneration are reviewed to provide an innovative research direction for endogenous repair and a new potential treatment strategy for IVd degeneration.
Journal ArticleDOI
MiR-138-5p promotes TNF-α-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling.
TL;DR: The knockout of miR-138-5p expression protected human NP cells from apoptosis via the upregulation of SIRT1, which was possibly mediated via PTEN/PI3K/Akt signaling.
Journal ArticleDOI
MicroRNAs: New players in intervertebral disc degeneration
TL;DR: With continued efforts, restoration of dysregulated miRNA expression may represent a promising biological treatment approach for mitigating or reversing IVD degeneration.
Journal ArticleDOI
Dysregulated miR-98 Contributes to Extracellular Matrix Degradation by Targeting IL-6/STAT3 Signaling Pathway in Human Intervertebral Disc Degeneration.
Ming-liang Ji,Jun Lu,Peiliang Shi,Xuejun Zhang,Shan-Zheng Wang,Qing Chang,Hui Chen,Chen Wang +7 more
TL;DR: Results suggest the downregulation of miR‐98 could promote IDD through the IL‐6/STAT3 signaling pathway and highlight miR•98 as a novel hopeful therapeutic target for IDD.
References
More filters
Journal ArticleDOI
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
TL;DR: It is shown that miR-10b is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion, and the workings of an undescribed regulatory pathway, in which a pleiotropic transcription factor induces expression of a specific microRNA, which suppresses its direct target and in turn activates another pro-metastatic gene, leading to tumour cell invasion and metastasis.
Journal ArticleDOI
What is intervertebral disc degeneration, and what causes it?
TL;DR: To suggest how intervertebral disc degeneration might be distinguished from the physiologic processes of growth, aging, healing, and adaptive remodeling, and to simplify the issue of causality.
Journal ArticleDOI
MicroRNAs in metabolism and metabolic disorders.
Veerle Rottiers,Anders M. Näär +1 more
TL;DR: Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that mi RNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.
Journal ArticleDOI
miRNAs in human cancer.
TL;DR: A critical overview of miRNA dysregulation in cancer is provided, first discussing the methods currently available for studying the role of miRNAs in cancer and then reviewing miRNA genomic organization, biogenesis and mechanism of target recognition.
Journal ArticleDOI
Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix.
TL;DR: Current research is aimed at trying to restore the integrity of the degenerate disc matrix by biologic means, although at present it is not clear what the structure of the most appropriate repair tissue should be or how it can be achieved.