Journal ArticleDOI
Mitochondrial Membrane Potential in Living Cells
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This article is published in Annual Review of Cell Biology.The article was published on 1988-01-01. It has received 1003 citations till now. The article focuses on the topics: Inner mitochondrial membrane & Translocase of the inner membrane.read more
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Mitochondrial Membrane Permeabilization in Cell Death
TL;DR: Once MMP has been induced, it causes the release of catabolic hydrolases and activators of such enzymes (including those of caspases) from mitochondria, meaning that mitochondria coordinate the late stage of cellular demise.
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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
TL;DR: It is demonstrated that LDH-A plays a key role in tumor maintenance as well as stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential in malignant cells.
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A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
Sébastien Bonnet,Stephen L. Archer,Joan Allalunis-Turner,Alois Haromy,Christian Beaulieu,Richard B. Thompson,Christopher T. Lee,Gary D. Lopaschuk,Lakshmi Puttagunta,Sandra Bonnet,Gwyneth Harry,Kyoko Hashimoto,Christopher J. Porter,Miguel A. Andrade,Bernard Thébaud,Evangelos D. Michelakis +15 more
TL;DR: The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted and the orally available DCA is a promising selective anticancer agent.
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A review of NIR dyes in cancer targeting and imaging.
TL;DR: It is believed these newly developed multifunctional NIR dyes will broaden current concept of tumor targeted imaging and hold promise to make an important contribution to the diagnosis and therapeutics for the treatment of cancer.
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Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives
TL;DR: Wavelength scanning of the surface fluorescence of the heart under various conditions after accumulation of T MRM indicated that the mitochondrial matrix-induced wavelength shift of TMRM also occurs in the heart cytosol, eliminating the use of this approach in the intact heart.
References
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Rhodamine 123 inhibits import of rat liver mitochondrial transhydrogenase
TL;DR: Results suggest that rhodamine 123 may inhibit import of the transhydrogenase precursor into mitochondria by disrupting components in the mitochondrial membrane necessary for efficient import.