Journal ArticleDOI
Modelling aspects of the biotechnological valorization of raw glycerol: production of citric acid by Yarrowia lipolytica and 1,3‐propanediol by Clostridium butyricum
TLDR
It has been demonstrated that the production of citric acid from raw glycerol, in terms of specific production rate and conversion yield, was similar or even better as compared with that obtained during cultivation of yeasts or molds on various conventional media.Abstract:
Raw glycerol, produced in significant quantities during several industrial processes, could be further considered as a potential substrate for microbial conversions. In the present report, modelling approaches are used in order to quantify the kinetic behavior of microorganisms capable of producing growth- and non growth-associated metabolites when cultivated on raw glycerol. Citric acid production by Yarrowia lipolytica strain ACA-DC 50109 was successfully simulated by Monod-, Verhlust- and Williams-type models, while the optimized parameter values were found to be similar to those experimentally measured. It has been demonstrated that the production of citric acid from raw glycerol, in terms of specific production rate and conversion yield, was similar or even better as compared with that obtained during cultivation of yeasts or molds on various conventional (eg sugar-based) media. The production of 1,3-propanediol by Clostridium butyricum strain F2b from raw glycerol was successfully simulated by a Contois-type model. It was found that the maximum theoretical 1,3-propanediol productivity was comparable with the highest one achieved during growth of various bacterial strains on pure glycerol in batch and continuous cultures. Raw glycerol could be used as an alternative substrate for citric acid and 1,3-propanediol production, and possibly for other microbial products. Copyright © 2003 Society of Chemical Industryread more
Citations
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Journal ArticleDOI
Value-added uses for crude glycerol--a byproduct of biodiesel production.
TL;DR: The majority of crude glycerol is used as feedstock for production of other value-added chemicals, followed by animal feeds, and the value- added utilization opportunities of crude Glycerol are reviewed.
Journal ArticleDOI
Microbial production of 1,3-propanediol: recent developments and emerging opportunities.
TL;DR: Present review gives an overview on 1,3-propanediol production by wild and recombinant strains, and attempts to encompass the various issues concerned in utilization of crude glycerol for 1, 3-pro panediolProduction, with particular emphasis laid on biodiesel industries.
Journal ArticleDOI
Lipids of oleaginous yeasts. Part II: Technology and potential applications
TL;DR: The process of lipid accumulation in the oleaginous yeasts cultivated in various fermentation configurations when either sugars and related compounds or hydrophobic substances are used as substrates is presented and kinetic models describing both de novo and ex novo lipid accumulation are analyzed.
Journal ArticleDOI
Commodity Chemicals Derived from Glycerol, an Important Biorefinery Feedstock
TL;DR: It has been proposed that renewable resources such as plant-derived sugars and other compounds be used to synthesize the compounds necessary for the production of pharmaceuticals, agricultural chemicals, plastics, and transportation fuels.
Journal ArticleDOI
Evaluating renewable carbon sources as substrates for single cell oil production by Cunninghamella echinulata and Mortierella isabellina.
Stylianos Fakas,Seraphim Papanikolaou,Athanasios Batsos,Maria Galiotou-Panayotou,Athanasios Mallouchos,George Aggelis +5 more
TL;DR: Significant differences in the process of lipid accumulation as related to the carbon sources used were observed for both microorganisms, and the growth of both C. echinulata and M. isabellina on raw glycerol resulted in lower yields in terms of both biomass and oil produced than the growth on xylose.
References
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A mathematical model for the continuous culture of microorganisms utilizing inhibitory substrates
TL;DR: The model should be of value in investigations of the stability of biological processes used for the treatment of certain industrial wastes such as those containing phenols, thiocyanates, nitrates, ammonia, volatile acids, etc., which are known to be inhibitory to many of the organisms metabolizing them.
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A kinetic study of the lactic acid fermentation. Batch process at controlled pH
Robert Luedeking,Edgar L. Piret +1 more
TL;DR: In this paper, the kinetics of the fermentation of glucose to lactic acid have been studied at six constant pH levels between 4·5 and 6·0 by measuring the instantaneous rates of bacterial growth and acid formation throughout each fermentation.
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Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture.
TL;DR: Yarrowia lipolytica LGAM S(7)1 presented remarkable growth on industrial glycerol used as sole carbon substrate whilst fat-free material yield increased over the whole range of D (h(-1)).
Journal ArticleDOI
Kinetics of product inhibition in alcohol fermentation
TL;DR: The inhibitory effect of ethanol concentration p in a medium on the specific rates of growth μ and ethanol production ν of a specific strain of baker's yeast was studied in a chemostat, where except for ethanol as the product, only the concentration of glucose S was controlled to limit the metabolic activity of the yeast.
Journal ArticleDOI
Yarrowia lipolytica as a potential producer of citric acid from raw glycerol
TL;DR: In this article, the biochemical response of Yarrowia lipolytica during growth on raw glycerol (the main byproduct of bio-diesel production units) in order to produce metabolic products of industrial significance was studied.