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MODELTEST: testing the model of DNA substitution.

David Posada, +1 more
- 01 Jan 1998 - 
- Vol. 14, Iss: 9, pp 817-818
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TLDR
The program MODELTEST uses log likelihood scores to establish the model of DNA evolution that best fits the data.
Abstract
Summary: The program MODELTEST uses log likelihood scores to establish the model of DNA evolution that best fits the data. Availability: The MODELTEST package, including the source code and some documentation is available at http://bioag.byu.edu/zoology/crandall―lab/modeltest.html. Contact: dp47@email.byu.edu.

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Dynamics of Dengue Disease Severity Determined by the Interplay Between Viral Genetics and Serotype-Specific Immunity

TL;DR: The data demonstrate that the complex interaction between viral genetics and population dynamics of serotype-specific immunity contributes to the risk of severe dengue disease and provide insights into viral evolution and the effects of a patient’s immunological background on viral fitness and virulence.
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Phylogeny and taxonomic revision of plastid-containing euglenophytes based on SSU rDNA sequence comparisons and synapomorphic signatures in the SSU rRNA secondary structure.

TL;DR: Sequence comparisons and a revised classification of the Euglenophyceae were based on 92 new SSU rDNA sequences obtained from strains of Euglena, Astasia, Phacus, Trachelomonas, Colacium, Cryptoglena, Lepocinclis, EUTreptia, Eutreptiella and TetreutrePTia, and one lineage was recognized as the previously neglected genus Monomorphina Mereschkowsky (1877).
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Phylogeny of Arthropoda inferred from mitochondrial sequences: strategies for limiting the misleading effects of multiple changes in pattern and rates of substitution.

TL;DR: The phylogenetic analyses support the existence of a major dichotomy within Arthropoda, separating Pancrustacea and Paradoxopoda, and it is recommended to select taxa and genes of the mitochondrial genome for inferring phylogenetic relationships among arthropod lineages.
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Historical biogeography, divergence times, and diversification patterns of bumble bees (Hymenoptera: Apidae: Bombus )

TL;DR: This work reconstructs the historical distribution of bumble bees in a temporal framework, estimating divergence times using fossil data and molecular rates derived from the literature, and reveals movements of Bombus concordant with geographic and climatic events of the late Cenozoic.
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Metagenomic Profile of the Bacterial Communities Associated with Ixodes ricinus Ticks

TL;DR: This study demonstrates a novel detection strategy for the microbiomes of arthropod vectors in the context of epidemiological and ecological studies and provides the most complete picture to date of the bacterial communities present within I. ricinus under natural conditions by using high-throughput sequencing technologies.
References
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Journal ArticleDOI

A new look at the statistical model identification

TL;DR: In this article, a new estimate minimum information theoretical criterion estimate (MAICE) is introduced for the purpose of statistical identification, which is free from the ambiguities inherent in the application of conventional hypothesis testing procedure.
Journal ArticleDOI

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.

TL;DR: Some examples were worked out using reported globin sequences to show that synonymous substitutions occur at much higher rates than amino acid-altering substitutions in evolution.
Journal ArticleDOI

Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.

TL;DR: A new statistical method for estimating divergence dates of species from DNA sequence data by a molecular clock approach is developed, and this dating may pose a problem for the widely believed hypothesis that the bipedal creatureAustralopithecus afarensis, which lived some 3.7 million years ago, was ancestral to man and evolved after the human-ape splitting.
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