Journal ArticleDOI
Modulation of GABAA receptor activity by phosphorylation and receptor trafficking: implications for the efficacy of synaptic inhibition
Josef T. Kittler,Stephen J. Moss +1 more
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TLDR
These regulatory mechanisms, which can be dynamically modulated by receptor trafficking and phosphorylation, are discussed and their consequences for the efficacy of GABA(A) receptor mediated synaptic inhibition are discussed.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2003-06-01. It has received 301 citations till now. The article focuses on the topics: GABAA-rho receptor & gamma-Aminobutyric acid.read more
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Variations on an inhibitory theme : phasic and tonic activation of GABA(A) receptors
Mark Farrant,Zoltan Nusser +1 more
TL;DR: This review considers the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability in the adult mammalian brain.
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GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
TL;DR: It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks.
Journal ArticleDOI
Receptor trafficking and synaptic plasticity
TL;DR: Insight into how these receptors are rapidly moved into and out of synaptic membranes has profound implications for the understanding of the mechanisms of long-term potentiation and long- term depression.
Journal ArticleDOI
International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update
Richard W. Olsen,Werner Sieghart +1 more
TL;DR: This review attempts to summarize experimental evidence on the existence of defined native GABAA receptor subtypes and to produce a list of receptors that actually seem to exist according to current knowledge, and proposes several criteria, which can be applied to all the members of the LGIC superfamily, for including a receptor subtype on a lists of native hetero-oligomeric subtypes.
Journal ArticleDOI
GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition
TL;DR: This Review discusses recent progress in the understanding of the dynamic regulation of GABAAR composition, trafficking to and from the neuronal surface, and lateral movement of receptors between synaptic and extrasynaptic locations.
References
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Journal ArticleDOI
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
Yukiko Kabeya,Noboru Mizushima,Noboru Mizushima,Takashi Ueno,Akitsugu Yamamoto,Takayoshi Kirisako,Takayoshi Kirisako,Takeshi Noda,Takeshi Noda,Eiki Kominami,Yoshinori Ohsumi,Yoshinori Ohsumi,Tamotsu Yoshimori,Tamotsu Yoshimori +13 more
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
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Molecular dissection of autophagy: two ubiquitin-like systems.
TL;DR: In this article, the genes required for autophagy in yeast have been analyzed and two ubiquitin-like systems were found to be involved in the membrane dynamics of the process.
Journal ArticleDOI
Subunit composition, distribution and function of GABA(A) receptor subtypes.
Werner Sieghart,Günther Sperk +1 more
TL;DR: Together, these results should cause a revival of GABA(A) receptor research and strongly stimulate the development of drugs with a higher selectivity for alpha2-, alpha3-, or alpha5-subunit-containing receptor subtypes.
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Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin.
TL;DR: The γ2 subunit and gephyrin are interdependent components of the same synaptic complex that is critical for postsynaptic clustering of abundant subtypes of GABAA receptors in vivo.
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GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.
TL;DR: A new cellular protein, GABAA-receptor-associated protein (GABARAP), is identified, which can interact with the γ2 subunit of GAB AA receptors and suggest a mechanism for the targeting and clustering of GabAA receptors.
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Subunit composition, distribution and function of GABA(A) receptor subtypes.
Werner Sieghart,Günther Sperk +1 more