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Modulation of Nrf2 expression alters high glucose-induced oxidative stress and antioxidant gene expression in mouse mesangial cells.
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TLDR
Results indicated that Nrf2 and its downstream antioxidants, HO-1 and γ-GCS, are negative regulators of high glucose-induced ROS-related mouse mesangial cell dysfunction.About:
This article is published in Cellular Signalling.The article was published on 2011-10-01. It has received 60 citations till now. The article focuses on the topics: Mesangial cell & Oxidative stress.read more
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Curcumin, inflammation, and chronic diseases: how are they linked?
TL;DR: Research to date suggests that chronic inflammation, oxidative stress, and most chronic diseases are closely linked, and the antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases.
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Mesangial cell biology.
TL;DR: Identification of biological responses of MCs that are not mediated by the renin-angiotensin system should help development of novel and effective therapeutic strategies to treat diseases characterized by MC pathology.
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Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds
Muthu K. Shanmugam,Jong Hyun Lee,Edna Zhi Pei Chai,Madhu Mathi Kanchi,Shreya Kar,Frank Arfuso,Arunasalam Dharmarajan,Alan Prem Kumar,Perumal Samy Ramar,Chung Yeng Looi,Mohammad Rais Mustafa,Vinay Tergaonkar,Anupam Bishayee,Kwang Seok Ahn,Gautam Sethi,Gautam Sethi +15 more
TL;DR: This review critically analyze the existing literature on the modulation of diverse transcription factors by various natural compounds and provides views on new directions for accelerating the discovery of novel drug candidates derived from Mother Nature.
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Thioredoxin-interacting Protein Mediates High Glucose-induced Reactive Oxygen Species Generation by Mitochondria and the NADPH Oxidase, Nox4, in Mesangial Cells
Anu Shah,Ling Xia,Ling Xia,Howard J. Goldberg,Howard J. Goldberg,Ken W. Lee,Susan E. Quaggin,Susan E. Quaggin,I. George Fantus +8 more
TL;DR: TxNIP deficiency protects mesangial cells from HG-induced oxidative stress and increased collagen by blocking mitochondrial glucose metabolism, NADPH oxidase, and Nox4 by regulating the TCA cycle versus glycolytic glucose flux.
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Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease
TL;DR: Current findings on the renoprotective effects of naturally occurring NRF2 activators, including sulforaphane, resveratrol, curcumin, and cinnamic aldehyde are described, bringing a light of hope for ameliorating CKD progression by preventing oxidative stress and maintaining cellular redox homeostasis.
References
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Journal ArticleDOI
Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
superoxide production blocks three pathways of hyperglycaemic damage
Takeshi Nishikawa,Diane Edelstein,Xue Liang Du,Sho-ichi Yamagishi,Takeshi Matsumura,Yasufumi Kaneda,Mark A. Yorek,David Beebek,Peter J. Oatesk,Hans-Peter Hammes,Ida Giardino,Michael Brownlee +11 more
TL;DR: This paper showed that hyperglycaemia increases the production of reactive oxygen species inside cultured bovine aortic endothelial cells and that this increase in reactive oxygen can be prevented by an inhibitor of electron transport chain complex II, an uncoupler of oxidative phosphorylation, by uncoupling protein-1 and by manganese superoxide dismutase.
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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Takeshi Nishikawa,Diane Edelstein,Xue Liang Du,Sho-ichi Yamagishi,Takeshi Matsumura,Yasufumi Kaneda,Mark A. Yorek,David A. Beebe,Peter J. Oates,Hans-Peter Hammes,Ida Giardino,Michael Brownlee +11 more
TL;DR: This work shows that hyperglycaemia increases the production of reactive oxygen species inside cultured bovine aortic endothelial cells and is prevented by an inhibitor of electron transport chain complex II, by an uncoupler of oxidative phosphorylation, by uncoupling protein-1 and by manganese superoxide dismutase.
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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Ken Itoh,Nobunao Wakabayashi,Yasutake Katoh,Tetsuro Ishii,Kazuhiko Igarashi,James Douglas Engel,James Douglas Engel,Masayuki Yamamoto +7 more
TL;DR: It is postulate that Keap1 and Nrf2 constitute a crucial cellular sensor for oxidative stress, and together mediate a key step in the signaling pathway that leads to transcriptional activation by this novel NRF2 nuclear shuttling mechanism.
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Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment.
TL;DR: Little is known about the impact of dietary antioxidants upon the development and progression of neurodegenerative diseases, especially Alzheimer’s disease, but there are many attempts to develop antioxidants that can cross the blood-brain barrier and decrease oxidative damage.