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Molecular biomimetics: nanotechnology through biology

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TLDR
This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds.
Abstract
Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed by using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically engineered to specifically bind to selected inorganic compounds for applications in nano- and biotechnology. This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds. These genetically engineered proteins for inorganics (GEPIs) can be used in the assembly of functional nanostructures. Based on the three fundamental principles of molecular recognition, self-assembly and DNA manipulation, we highlight successful uses of GEPI in nanotechnology.

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Protein-directed approaches to functional nanomaterials: a case study of lysozyme.

TL;DR: The use of lysozyme as a model protein to the direct synthesis of nanomaterials and the lessons from this case study will provide invaluable guidance in future materials design using proteins and other biomolecules are highlighted.
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Preparation and characterization of the biomineralized zinc oxide particles in spider silk peptides

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The influence of tissue microenvironment on stem cell-based cartilage repair.

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Hematite nanostructures synthesized by a silk fibroin-assisted hydrothermal method

TL;DR: It is believed that such a synthesis method of α-Fe2O3 provides an efficient shape control and cost-effective approach that is potentially competitive for scaling-up industrial production.
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Applications of biomimetic systems in drug delivery.

TL;DR: This review article highlights recent activities in the field of biomimetic systems and their application in controlled drug delivery, with a focus on synthesis and assembly for the creation of novel biomaterials.
References
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Journal ArticleDOI

A study of the nucleation and growth processes in the synthesis of colloidal gold

TL;DR: In this paper, a preliminary survey with the electron microscope of various preparations of colloidal gold, a study was made of the process of nucleation and growth in gold colloids, and it was shown that nucleating agents may be identified with reducing agents which form a mixed polymer with chlorauric ion before the reduction to the nucleus takes place.
Journal ArticleDOI

Shape-Controlled Synthesis of Gold and Silver Nanoparticles

TL;DR: Monodisperse samples of silver nanocubes were synthesized in large quantities by reducing silver nitrate with ethylene glycol in the presence of poly(vinyl pyrrolidone) (PVP), characterized by a slightly truncated shape bounded by {100, {110}, and {111} facets.
Journal ArticleDOI

Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

TL;DR: Foreign DNA fragments can be inserted into filamentous phage gene III to create a fusion protein with the foreign sequence in the middle that is incorporated into the virion, which retains infectivity and displays the foreign amino acids in immunologically accessible form.
PatentDOI

Self-assembly and mineralization of peptide-amphiphile nanofibers

TL;DR: In this paper, pH-induced self-assembly of a peptide-amphiphile was used to make a nanostructured fibrous scaffold reminiscent of extracellular matrix.
Journal ArticleDOI

Molecular self-assembly and nanochemistry: a chemical strategy for the synthesis of nanostructures.

TL;DR: The ability to prepare structures in the upper part of this range of sizes would open a route to structures comparable in size (and perhaps complementary in function) to those that can be prepared by microlithography and other techniques of microfabrication.
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