Molecular pathways associated with oxidative stress in diabetes mellitus
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TLDR
Increased level of glyceraldehyde-3-P activates two major pro-oxidative pathways in diabetes, which causes the accumulation of glycolytic metabolites upstream, and this leads to excessive stimulation of other pro-oxygenative pathways such as hexosamine and polyol pathways.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2018-12-01 and is currently open access. It has received 259 citations till now. The article focuses on the topics: Methylglyoxal & Protein kinase C.read more
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Oxidative Stress and Microvascular Alterations in Diabetic Retinopathy: Future Therapies.
TL;DR: This review focuses on analysing the sources and effects of oxidative stress and inflammation on vascular alterations and diabetic retinopathy development, and current and antioxidant therapies, together with new molecular targets, are postulated for diabetic Retinopathy treatment.
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Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury.
Chunyan Wang,Wenlin Yuan,Anmin Hu,Juan Lin,Zhengyuan Xia,Catherine F. Yang,Yalan Li,Zhongjun Zhang +7 more
TL;DR: The attenuation of sepsis-induced HO-1 overexpression and iron concentration, and the reduction of ferroptosis via enhancing GPX4, may be the major mechanisms via which Dex alleviates sepsi-induced myocardial cellular injury.
Journal ArticleDOI
Therapeutic potential of mushrooms in diabetes mellitus: Role of polysaccharides.
TL;DR: The present review discusses the pathophysiology of diabetes and, elaborates some potential mushroom species that are known to have antihyperglycemic activities and different mushroom polysaccharides modulating the composition of gut microflora in diabetic animal models have also been discussed.
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Limonoids from Citrus: Chemistry, anti-tumor potential, and other bioactivities
Yu-Sheng Shi,Yu-Sheng Shi,Yan Zhang,Hao-Tian Li,Chuanhai Wu,Hesham R. El-Seedi,Hesham R. El-Seedi,Wen-Kang Ye,Wen-Kang Ye,Zi-Wei Wang,Chun-Bin Li,Xu-Fu Zhang,Guoyin Kai +12 more
TL;DR: Citrus limonoids are tetranortriterpenoids compounds mainly found in oranges, lemons, grapefruits, and other fruits of Citrus and are proved to be the leading cause of bitterness in Citrus fruits.
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Antioxidant and cytoprotective effect of peptides produced by hydrolysis of whey protein concentrate with trypsin.
María Belén Ballatore,Marina del Rosario Bettiol,Noelia Luciana Vanden Braber,Carla Aylen Aminahuel,Yanina Estefanía Rossi,Gabriela Petroselli,Rosa Erra-Balsells,Lilia René Cavaglieri,Mariana Angélica Montenegro,Mariana Angélica Montenegro +9 more
TL;DR: Strong antioxidant and cytoprotective peptides were obtained from a low-cost dairy industry product, which could improve consumers' health when used as functional ingredients.
References
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Oxidative stress and diabetic complications
TL;DR: Athrosclerosis and cardiomyopathy in type 2 diabetes are caused in part by pathway-selective insulin resistance, which increases mitochondrial ROS production from free fatty acids and by inactivation of antiatherosclerosis enzymes by ROS.
superoxide production blocks three pathways of hyperglycaemic damage
Takeshi Nishikawa,Diane Edelstein,Xue Liang Du,Sho-ichi Yamagishi,Takeshi Matsumura,Yasufumi Kaneda,Mark A. Yorek,David Beebek,Peter J. Oatesk,Hans-Peter Hammes,Ida Giardino,Michael Brownlee +11 more
TL;DR: This paper showed that hyperglycaemia increases the production of reactive oxygen species inside cultured bovine aortic endothelial cells and that this increase in reactive oxygen can be prevented by an inhibitor of electron transport chain complex II, an uncoupler of oxidative phosphorylation, by uncoupling protein-1 and by manganese superoxide dismutase.