Journal ArticleDOI
Morphologic Features and Glial Activation in Rat Oxaliplatin-Dependent Neuropathic Pain
Lorenzo Di Cesare Mannelli,Alessandra Pacini,Laura Bonaccini,Matteo Zanardelli,Tommaso Mello,Carla Ghelardini +5 more
TLDR
Data highlight the relevance of glial cells in chemotherapy-induced neurotoxicity as part of the investigation of the role that specific brain areas play in neuropathy.About:
This article is published in The Journal of Pain.The article was published on 2013-12-01. It has received 151 citations till now. The article focuses on the topics: Nervous system & Astrocyte.read more
Citations
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Journal ArticleDOI
Mechanisms of Chemotherapy-Induced Peripheral Neuropathy.
Renata Zajączkowska,Magdalena Kocot-Kępska,Wojciech Leppert,Anna Wrzosek,Joanna Mika,Jerzy Wordliczek +5 more
TL;DR: A better understanding of the risk factors and underlying mechanisms of CIPN is needed to develop effective preventive and therapeutic strategies and the neurotoxicity mechanisms of the most common antineoplastic agents are reviewed.
Journal ArticleDOI
Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain
TL;DR: The failure of previously tested antioxidants, neuroprotective agents, anticonvulsants and antidepressants as therapeutic or preventative strategies are discussed, and individualized, mechanism-based therapeutic options for CIPNP associated with each of the three main drug groups are suggested.
Journal ArticleDOI
Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy.
Preet G.S. Makker,Samuel S. Duffy,Justin G. Lees,Chamini J. Perera,Ryan S. Tonkin,Oleg Butovsky,Susanna B. Park,David Goldstein,Gila Moalem-Taylor +8 more
TL;DR: It is suggested that PTX and OXA cause distinct pathological changes in the periphery and nervous system, which may contribute to chemotherapy-induced neuropathic pain.
Journal ArticleDOI
CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain.
Karen Krukowski,Niels Eijkelkamp,Geoffroy Laumet,C. Erik Hack,Yan Li,Patrick M. Dougherty,Cobi Jacoba Johanna Heijnen,Annemieke Kavelaars +7 more
TL;DR: A novel mechanism for resolution of CIPN is identified that requires CD8+ T cells and endogenous interleukin (IL)-10 and that IL-10 suppresses the abnormal paclitaxel-induced spontaneous discharges by DRG neurons to promote recovery from CIPn.
Journal ArticleDOI
Mechanisms of chemotherapy-induced behavioral toxicities
Elisabeth G. Vichaya,Gabriel S. Chiu,Karen Krukowski,Tamara E. Lacourt,Annemieke Kavelaars,Robert Dantzer,Cobi J. Heijnen,Adam K. Walker +7 more
TL;DR: It is argued that, based on the available evidence, neuroinflammation is unlikely the only mechanism involved in the pathogenesis of chemotherapy-induced behavioral toxicities, and two other putative candidate mechanisms are evaluated.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer
A. de Gramont,A. Figer,M. Seymour,M. Homerin,A. Hmissi,J. Cassidy,Corrado Boni,H. Cortes-Funes,Andrés Cervantes,Gilles Freyer,Demetris Papamichael,N. Le Bail,C. Louvet,D. Hendler,F. de Braud,C. Wilson,Francois Morvan,Andrea Bonetti +17 more
TL;DR: The LV5FU2-oxaliplatin combination seems beneficial as first-line therapy in advanced colorectal cancer, demonstrating a prolonged progression-free survival with acceptable tolerability and maintenance of QoL.
Journal ArticleDOI
Oxaliplatin, Fluorouracil, and Leucovorin as Adjuvant Treatment for Colon Cancer
Thierry André,Corrado Boni,Lamia Mounedji-Boudiaf,Matilde Navarro,Josep Tabernero,Tamas Hickish,C. Topham,Marta Zaninelli,Phillip Clingan,John Bridgewater,Isabelle Tabah-Fisch,Aimery de Gramont +11 more
TL;DR: Adding oxaliplatin to a regimen of fluorouracil and leucovorin improves the adjuvant treatment of colon cancer.
Journal ArticleDOI
The neuropathic pain triad: neurons, immune cells and glia
Joachim Scholz,Clifford J. Woolf +1 more
TL;DR: Immunosuppression and blockade of the reciprocal signaling pathways between neuronal and non-neuronal cells offer new opportunities for disease modification and more successful management of pain.
Journal ArticleDOI
Pathological and protective roles of glia in chronic pain
TL;DR: The current understanding of the contribution of glia to pathological pain and neuroprotection is reviewed, and how the protective, anti-inflammatory actions ofglia are being harnessed to develop new drug targets for neuropathic pain control is reviewed.
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