Mortality rates and age at death from sickle cell disease: U.S., 1979-2005.
TLDR
These data confirm prior findings of a significant decrease in mortality for children with SCD and appear to have increased during the same time period It seems unlikely that this increase is due merely to an influx of younger patients surviving to adulthood and may reflect a lack of access to high-quality care for adults withSCD.Abstract:
Objectives.Improvements in survival for children with sickle cell disease (SCD) during the last 30 years have been well established. Whether similar improvements for adults with the disease have oc...read more
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Sickle Cell Disease
TL;DR: Studies from past decades related to such translational research as the use of hydroxyurea in treatment, as well as the therapeutic promise of red-cell ion-channel blockers, and antiadhesion and anti-inflammatory therapy are highlighted.
Journal ArticleDOI
Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation
Eliane Gluckman,Barbara Cappelli,Françoise Bernaudin,Myriam Labopin,Fernanda Volt,Jeanette Carreras,Belinda Pinto Simões,Alina Ferster,Sophie Dupont,Josu de la Fuente,Jean-Hugues Dalle,Marco Zecca,Mark C. Walters,Lakshmanan Krishnamurti,Monica Bhatia,Kathryn S. Leung,Gregory A. Yanik,Joanne Kurtzberg,Nathalie Dhedin,Mathieu Kuentz,Gérard Michel,Jane F. Apperley,Patrick Lutz,Bénédicte Neven,Yves Bertrand,J.P. Vannier,Mouhab Ayas,Marina Cavazzana,Marina Cavazzana,Marina Cavazzana,Susanne Matthes-Martin,Vanderson Rocha,Vanderson Rocha,Vanderson Rocha,Hanadi Elayoubi,Chantal Kenzey,Peter Bader,Franco Locatelli,Annalisa Ruggeri,Mary Eapen +39 more
TL;DR: The excellent outcome of a cohort transplanted over the course of 3 decades confirms the role of HLA-identical sibling transplantation for children and adults with SCD.
Journal ArticleDOI
Survival in adults with sickle cell disease in a high-income setting
Kate Gardner,Kate Gardner,Abdellah Douiri,Abdellah Douiri,Abdellah Douiri,Emma Drasar,Emma Drasar,Marlene Allman,Anne Mwirigi,Moji Awogbade,Swee Lay Thein,Swee Lay Thein +11 more
TL;DR: Survival of patients with sickle cell disease in high-income countries has improved greatly in the last 60 years.
Journal ArticleDOI
Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease.
Deborah P. Lubeck,Irene Agodoa,Nickhill Bhakta,Mark D. Danese,Kartik Pappu,Robin S. Howard,Michelle Gleeson,Marc Halperin,Sophie Lanzkron +8 more
TL;DR: Sickle cell disease appears to have important societal consequences in terms of reductions in life expectancy and lifetime income, underscoring the need for disease-modifying therapies to improve sickle cell disease–related morbidity and mortality.
Journal ArticleDOI
Evolution of sickle cell disease from a life-threatening disease of children to a chronic disease of adults: The last 40 years.
TL;DR: Over the past 40 years, public health measures such as universal newborn screening, penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive decline in sickle cell disease (SCD)‐related childhood mortality and SCD‐related morbidity in high‐income countries.
References
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Regression Models for Categorical Dependent Variables Using Stata
J. Scott Long,Jeremy Freese +1 more
TL;DR: In this article, the authors present a brief tutorial for estimating, testing, fit, and interpretation of ordinal and binary outcomes using Stata. But they do not discuss how to apply these models to other estimation commands, such as post-estimation analysis.
Book
Regression Models for Categorical Dependent Variables Using Stata, Second Edition
J. Scott Long,Jeremy Freese +1 more
TL;DR: This book discusses models for ordinal and nominal independent variables, and describes the development of models for Nominal Outcomes with Case-Specific Data and its use in Stata.
Journal ArticleDOI
Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early Death
Orah S. Platt,Donald Brambilla,Wendell F. Rosse,Paul F. Milner,Oswaldo Castro,Martin H. Steinberg,Panpit P. Klug +6 more
TL;DR: Modeling revealed that in patients with sickle cell anemia, the acute chest syndrome, renal failure, seizures, a base-line white-cell count above 15,000 cells per cubic millimeter, and a low level of fetal hemoglobin were associated with an increased risk of early death.
Related Papers (5)
Management of Sickle Cell Disease: Summary of the 2014 Evidence-Based Report by Expert Panel Members
Barbara P. Yawn,George R. Buchanan,Araba Afenyi-Annan,Samir K. Ballas,Kathryn L. Hassell,Andra H. James,Lanetta B. Jordan,Sophie Lanzkron,Richard Lottenberg,William J. Savage,Paula Tanabe,Russell E. Ware,M. Hassan Murad,Jonathan C. Goldsmith,Jonathan C. Goldsmith,Eduardo Ortiz,Robinson Fulwood,Ann Horton,Joylene John-Sowah +18 more
Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)
Winfred C. Wang,Russell E. Ware,Scott T. Miller,Rathi V. Iyer,James F. Casella,Caterina P. Minniti,Sohail Rana,Courtney D. Thornburg,Zora R. Rogers,Ram Kalpatthi,Julio C. Barredo,R. Clark Brown,Sharada A. Sarnaik,Thomas H. Howard,Lynn W. Wynn,Abdullah Kutlar,F. Daniel Armstrong,Beatrice Files,Jonathan C. Goldsmith,Myron A. Waclawiw,Xiangke Huang,Bruce W. Thompson +21 more