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Multidrug resistance reversal agents.
Jacques Robert,Christian Jarry +1 more
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This article is published in Journal of Medicinal Chemistry.The article was published on 2003-10-10. It has received 281 citations till now.read more
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Targeting multidrug resistance in cancer
Gergely Szakács,Jill K. Paterson,Joseph A. Ludwig,Catherine Booth-Genthe,Michael M. Gottesman +4 more
TL;DR: Various approaches to combating multidrug-resistant cancer are described, including the development of drugs that engage, evade or exploit efflux by ABC transporters.
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Fluorine in medicinal chemistry: A review of anti-cancer agents
TL;DR: In this paper, a review of fluorinated compounds which have found a role as anti-cancer agents is presented, highlighting the important drugs but also highlighting the latest developments on emerging compounds.
Journal ArticleDOI
ABC multidrug transporters: structure, function and role in chemoresistance
TL;DR: Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be responsible for chemoresistance and the effect of various genotypes and haplotypes on the expression and function of these proteins is not yet clear, and their true impact remains controversial.
Journal ArticleDOI
ABC efflux pump-based resistance to chemotherapy drugs.
TL;DR: The results confirmed the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the ABC Superfamily.
Journal ArticleDOI
Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy
TL;DR: The sustained, controlled and targeted delivery of chemotherapeutic drugs in a combination approach enhanced therapeutic anticancer effects with reduced drug-associated side effects is summarized.
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Journal ArticleDOI
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
Franz Thiebaut,Takashi Tsuruo,Hirofumi Hamada,Michael M. Gottesman,Ira Pastan,Mark C. Willingham +5 more
TL;DR: The results suggest that the protein has a role in the normal secretion of metabolites and certain anti-cancer drugs into bile, urine, and directly into the lumen of the gastrointestinal tract.
Journal ArticleDOI
Mechanisms of cancer drug resistance
TL;DR: The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance as mentioned in this paper.
Journal ArticleDOI
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
Alfred H. Schinkel,J. J. M. Smit,O. van Tellingen,Jos H. Beijnen,Els Wagenaar,L. Van Deemter,C. A. A. M. Mol,M. A. Van Der Valk,E. Robanus-Maandag,H te Riele,Anton Berns,Piet Borst +11 more
TL;DR: The findings explain some of the side effects in patients treated with a combination of carcinostatics and P-glycoprotein inhibitors and indicate that these inhibitors might be useful in selectively enhancing the access of a range of drugs to the brain.
Journal ArticleDOI
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
Suresh V. Ambudkar,Saibal Dey,Christine A. Hrycyna,Murali Ramachandra,Ira Pastan,Michael M. Gottesman +5 more
TL;DR: This review summarizes current research on the structure-function analysis of P-glycoprotein, its mechanism of action, and facts and speculations about its normal physiological role.
Journal ArticleDOI
Acute Myeloid Leukemia in the Elderly: Assessment of Multidrug Resistance (MDR1) and Cytogenetics Distinguishes Biologic Subgroups With Remarkably Distinct Responses to Standard Chemotherapy. A Southwest Oncology Group Study
Catherine P. Leith,Kenneth J. Kopecky,John E. Godwin,Thomas S. McConnell,Marilyn L. Slovak,I-Ming Chen,David R. Head,Frederick R. Appelbaum,Cheryl L. Willman +8 more
TL;DR: Investigation of biologic parameters at diagnosis in AML in the elderly may help identify patients with a high likelihood of achieving CR with conventional regimens, as well as those who may require alternate regimens designed to overcome therapy resistance.