Multiple developmental roles of vegf suggested by a lacz-tagged allele
Lucile Miquerol,Marina Gertsenstein,Kendraprasad Harpal,Janet Rossant,Janet Rossant,Andras Nagy,Andras Nagy +6 more
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TLDR
It is believed that the LacZ-tagged allele generated offers a precise means of detecting VEGF expression under a variety of physiological and pathological conditions.About:
This article is published in Developmental Biology.The article was published on 1999-08-15 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Vascular endothelial growth factor & Angiogenesis.read more
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Signaling Mechanisms Regulating Endothelial Permeability
Dolly Mehta,Asrar B. Malik +1 more
TL;DR: This review summarizes and analyzes the recent data from genetic, physiological, cellular, and morphological studies that have addressed the signaling mechanisms involved in the regulation of both the paracellular and transcellular transport pathways.
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Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
Vera Eremina,Manish M. Sood,Jody J. Haigh,Andras Nagy,Ginette Lajoie,Napoleone Ferrara,Hans-Peter Gerber,Yamato Kikkawa,Jeffrey H. Miner,Susan E. Quaggin +9 more
TL;DR: The data demonstrate that tight regulation of VEGF-A signaling is critical for establishment and maintenance of the glomerular filtration barrier and strongly supports a pivotal role for VEGf-A in renal disease.
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Endothelial cells and VEGF in vascular development
TL;DR: New insights into non-vascular roles of vascular endothelial growth factor and the requirement for endothelial cells in adult organs and stem-cell niches highlight possible side effects of anti-angiogenic therapy and the need for new targets.
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Autocrine VEGF Signaling Is Required for Vascular Homeostasis
Sunyoung Lee,Tom T. Chen,Chad L. Barber,Maria C. Jordan,Jared Murdock,Sharina Palencia Desai,Napoleone Ferrara,Andras Nagy,Kenneth P. Roos,M. Luisa Iruela-Arispe +9 more
TL;DR: A cell-autonomous VEGF signaling pathway that holds significance for vascular homeostasis but is dispensable for the angiogenic cascade is revealed.
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Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
Alessandro Fantin,Joaquim M. Vieira,Gaia Gestri,Laura Denti,Quenten Schwarz,Sergey V. Prykhozhij,Francesca Peri,Stephen W. Wilson,Christiana Ruhrberg +8 more
TL;DR: It is shown that tissue macrophages promote tip cell fusion downstream of VEGF-mediated tip cell induction, and that they could equally well be exploited to stimulate tissue vascularization in ischemic disease.
References
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Mechanisms of angiogenesis
TL;DR: Understanding of the molecular basis underlying angiogenesis, particularly from the study of mice lacking some of the signalling systems involved, has greatly improved, and may suggest new approaches for treating conditions such as cancer that depend onAngiogenesis.
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Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
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The biology of vascular endothelial growth factor
TL;DR: The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.
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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Peter Carmeliet,Valérie Ferreira,Georg Breier,Saskia Pollefeyt,Lena Kieckens,Marina Gertsenstein,Michaela Fahrig,Ann Vandenhoeck,Kendraprasad Harpal,Carmen Eberhardt,Cathérine Declercq,Judy Pawling,Lieve Moons,Desire Collen,Werner Risau,Andras Nagy,Andras Nagy +16 more
TL;DR: It is reported that formation of blood vessels was abnormal, but not abolished, in heterozygous VEGF-deficient (VEGF+/-) embryos, generated by aggregation of embryonic stem (ES) cells with tetraploid embryos (T-ES)16,17, and even more impaired in homozygous D1-VEGF- deficient (VDGF-/-) T-ES embryos, resulting in death at mid-gestation.
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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.
Fouad Shalaby,Janet Rossant,Janet Rossant,Terry P. Yamaguchi,Terry P. Yamaguchi,Marina Gertsenstein,Xiang-Fu Wu,Xiang-Fu Wu,Martin L. Breitman,Martin L. Breitman,Andre C. Schuh +10 more
TL;DR: The generation of mice deficient in Flk-1 by disruption of the gene using homologous recombination in embryonic stem (ES) cells is reported, indicating that FlK-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo.