Multitargeted therapy of cancer by silymarin.
TLDR
The protective effects of silymarin and its major active constituent, silibinin, studied in various tissues, suggest a clinical application in cancer patients as an adjunct to established therapies, to prevent or reduce chemotherapy as well as radiotherapy-induced toxicity.About:
This article is published in Cancer Letters.The article was published on 2008-10-08 and is currently open access. It has received 369 citations till now. The article focuses on the topics: Silibinin & Milk Thistle.read more
Citations
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Journal ArticleDOI
Milk thistle in liver diseases: past, present, future.
TL;DR: Silymarin has been used to treat alcoholic liver disease, acute and chronic viral hepatitis and toxin‐induced liver diseases, and may act as a toxin blockade agent by inhibiting binding of toxins to the hepatocyte cell membrane receptors.
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Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
TL;DR: In animal nutrition and disease prevention strategy, SM alone, or in combination with other hepatho-active compounds (carnitine, betaine, vitamin B12, etc.), might have similar hepatoprotective effects as described in human nutrition.
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Plant-derived anticancer agents: A green anticancer approach
Javed Iqbal,Banzeer Ahsan Abbasi,Tariq Mahmood,Sobia Kanwal,Barkat Ali,Sayed Afzal Shah,Ali Talha Khalil,Ali Talha Khalil +7 more
TL;DR: Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors.
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Antioxidant Therapy: Current Status and Future Prospects
TL;DR: Recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed and some suggestions are provided to be considered if antioxidant therapy is to succeed as an effective therapeutic strategy.
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Pathogenesis of alcoholic liver disease: Role of oxidative metabolism
TL;DR: Ethanol oxidative metabolism influences intracellular signaling pathways and deranges the transcriptional control of several genes, leading to fat accumulation, fibrogenesis and activation of innate and adaptive immunity, which plays a key role in the development and progression of ALD.
References
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Journal Article
Silymarin Suppresses TNF-Induced Activation of NF-κB, c-Jun N-Terminal Kinase, and Apoptosis
TL;DR: The inhibition of activation of NF-κB and the kinases may provide in part the molecular basis for the anticarcinogenic and anti-inflammatory effects of silymarin, and its effects on caspases may explain its role in cytoprotection.
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Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system
Wei Wu,Yang Wang,Li Que +2 more
TL;DR: It was concluded that bioavailability of silymarin was enhanced greatly by SMEDDS and alternative mechanisms, such as improved lymphatic transport pathway, other than improved release may contribute to enhancement of bio availability of slymarin.
Journal Article
Anticancer potential of silymarin: from bench to bed side.
TL;DR: Silymarin is a chemopreventive agent in vivo against a variety of carcinogens/tumor promoters, including UV light, 7,12-dimethylbenz(a)anthracene (DMBA), phorbol 12-myristate 13-acetate (PMA) and others.
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A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients.
Thomas W. Flaig,Daniel L. Gustafson,Lih-Jen Su,Joseph A. Zirrolli,Frances Crighton,Gail S. Harrison,A. Scott Pierson,Rajesh Agarwal,L. Michael Glode +8 more
TL;DR: It is concluded that 13 g of oral silybin-phytosome daily, in 3 divided doses, appears to be well tolerated in patients with advanced prostate cancer and is the recommended phase II dose.
Journal Article
A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
Parris M. Kidd,Kathleen A. Head +1 more
TL;DR: Silybin-phosphatidylcholine complexed as a phytosome provides significant liver protection and enhanced bioavailability over conventional silymarin.