Mycotic keratitis: epidemiology, diagnosis and management
P.A. Thomas,J. Kaliamurthy +1 more
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TLDR
The PCR has gained prominence as a diagnostic aid for mycotic keratitis, being used to complement microbiological methods; more importantly, this molecular method permits rapid specific identification of the aetiological agent.About:
This article is published in Clinical Microbiology and Infection.The article was published on 2013-03-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Fungal keratitis & Keratitis.read more
Citations
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Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the infectious diseases society of America
Thomas F. Patterson,George Richard Thompson,David W. Denning,Jay A. Fishman,Susan Hadley,Raoul Herbrecht,Dimitrios P. Kontoyiannis,Kieren A. Marr,Vicki A. Morrison,M. Hong Nguyen,Brahm H. Segal,William J. Steinbach,David A. Stevens,Thomas J. Walsh,John R. Wingard,Jo Anne H. Young,John E. Bennett +16 more
TL;DR: IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.
Journal ArticleDOI
ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi
Anuradha Chowdhary,Jacques F. Meis,Josep Guarro,G.S. de Hoog,Shallu Kathuria,Maiken Cavling Arendrup,S. Arikan-Akdagli,Murat Akova,Teun Boekhout,Morena Caira,Jesús Guinea,Jesús Guinea,Arunaloke Chakrabarti,Eric Dannaoui,A.D. van Diepeningen,Tomáš Freiberger,Andreas H. Groll,William W. Hope,Elizabeth M. Johnson,Michaela Lackner,Katrien Lagrou,Fanny Lanternier,Fanny Lanternier,Cornelia Lass-Flörl,O. Lortholary,O. Lortholary,Joseph Meletiadis,Patricia Muñoz,Patricia Muñoz,Livio Pagano,George Petrikkos,Malcolm Richardson,Emmanuel Roilides,Anna Skiada,Anna Maria Tortorano,Andrew J. Ullmann,Paul E. Verweij,Oliver A. Cornely,Manuel Cuenca-Estrella +38 more
TL;DR: Oral itraconazole has been considered the drug of choice, given the extensive clinical experience with this drug, but voriconazole may presumably be superior for central nervous system infections because of its ability to achieve good levels in the cerebrospinal fluid.
Journal ArticleDOI
Current Thoughts in Fungal Keratitis: Diagnosis and Treatment
TL;DR: This review will discuss current diagnostic modalities of fungal keratitis and will particularly focus on treatment regimens, and explore future therapeutic models and critique the potential benefit of each.
Journal ArticleDOI
An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells
Anthony J. St. Leger,Jigar V. Desai,Rebecca A. Drummond,Abirami Kugadas,Fatimah Almaghrabi,Phyllis B. Silver,Kumarkrishna Raychaudhuri,Mihaela Gadjeva,Yoichiro Iwakura,Michail S. Lionakis,Rachel R. Caspi +10 more
TL;DR: A mouse model of ocular surface disease is used to reveal that commensals were present in the ocular mucosa and had functional immunological consequences, providing direct evidence that a resident commensal microbiome exists on the Ocular surface and identify the cellular mechanisms underlying its effects on ocular immune homeostasis and host defense.
Journal ArticleDOI
Scedosporium and Lomentospora: an updated overview of underrated opportunists.
Andoni Ramirez-Garcia,Aize Pellon,Aitor Rementeria,Idoia Buldain,Eliana Barreto-Bergter,Rodrigo Rollin-Pinheiro,Jardel Vieira de Meirelles,Mariana Ingrid Dutra da Silva Xisto,Stéphane Ranque,Vladimír Havlíček,Patrick Vandeputte,Yohann Le Govic,Jean-Philippe Bouchara,Sandrine Giraud,Sharon C.-A. Chen,Johannes Rainer,Ana Alastruey-Izquierdo,María Teresa Martín-Gómez,Leyre M. López-Soria,Javier Pemán,Carsten Schwarz,Anne Bernhardt,Kathrin Tintelnot,Javier Capilla,Adela Martin-Vicente,José F. Cano-Lira,Markus Nagl,Michaela Lackner,Laszlo Irinyi,Wieland Meyer,Sybren de Hoog,Fernando L. Hernando +31 more
TL;DR: The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.
References
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Journal ArticleDOI
Evaluation of molecular diagnosis in fungal keratitis. Ten years of experience.
Consuelo Ferrer,Jorge L. Alió +1 more
TL;DR: PCR not only proved to be an effective rapid method for the diagnosis of fungal keratitis but was also more sensitive than stain and culture methods.
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Fungal keratitis in the United Kingdom 2003-2005.
Stephen J. Tuft,Andrew B Tullo +1 more
TL;DR: This study provides evidence of frequent delay in diagnosis after presentation to eye departments, inconsistent management, and poor outcome in fungal keratitis in the United Kingdom.
Journal ArticleDOI
Voriconazole versus natamycin as primary treatment in fungal corneal ulcers
TL;DR: The objective was to evaluate the efficacy of topical 1% voriconazole versus 5% natamycin in treatment of fungal corneal ulcers.
Journal ArticleDOI
Predictors of outcome in fungal keratitis
N. Venkatesh Prajna,Tiruvengada Krishnan,Jeena Mascarenhas,Muthiah Srinivasan,Catherine E. Oldenburg,Christine M. Toutain-Kidd,Aileen Sy,Stephen D. McLeod,Michael E. Zegans,Nisha R. Acharya,Thomas M. Lietman,Travis C. Porco +11 more
TL;DR: Ulcer severity at presentation is highly predictive of worse outcomes in fungal keratitis, and presentation of clinical characteristics such as baseline acuity and infiltrate scar can provide important information to clinicians about prognosis, and may help guide management and treatment decisions.
Journal ArticleDOI
Corneal nerve alterations in acute Acanthamoeba and fungal keratitis: an in vivo confocal microscopy study.
TL;DR: In this paper, the authors performed a retrospective analysis of laser in vivo confocal microscopy (IVCM) images of 10 acute Acanthamoeba keratitis (AK) and 4 fungal kitharisitis (FK) corneas.