Journal ArticleDOI
N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice
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TLDR
A reduction in Shati/Nat8l mRNA expression in the dorsal hippocampus of mice as a result of their aging is observed, and decreased N-acetyl aspartate (NAA) in aged mice was upregulated by Shatin8l overexpression, suggesting that the Shati-Nat8L-NAA pathway determines cognitive function with aging.About:
This article is published in Neurochemical Research.The article was published on 2022-04-15. It has received 3 citations till now. The article focuses on the topics: Medicine & Hippocampus.read more
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Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer’s Disease Model Mice
Kakeru Chino,Naotaka Izuo,H Noike,Kyosuke Uno,Tomoharu Kuboyama,Chihiro Tohda,Shin-ichi Muramatsu,Atsumi Nitta +7 more
TL;DR: Results suggest that Shati/Nat8l overexpression prevents cognitive dysfunction in 5XFAD mice, indicating that Shatisati/ Nat8l could be a therapeutic target for AD.
Journal ArticleDOI
Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer’s Disease Model Mice
Kakeru Chino,Naotaka Izuo,H Noike,Kyosuke Uno,Tomoharu Kuboyama,Chihiro Tohda,Shin-ichi Muramatsu,Atsumi Nitta +7 more
Journal ArticleDOI
Oolong tea polyphenols affect the inflammatory response to improve cognitive function by regulating gut microbiota
TL;DR: In this paper , OTP treatment restored the gut microbiota disruption including upregulated the relative abundance of Akkermansia and Muribaculum, and downregulated Desulfovibrio.
References
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