NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis
Andrey Lozhkin,Aleksandr E. Vendrov,Hua Pan,Samuel A. Wickline,Nageswara R. Madamanchi,Marschall S. Runge +5 more
TLDR
The data demonstrate that increased expression and activation of NOX4, which might result from increased TGFβ1 levels seen during aging, induces a proinflammatory phenotype in VSMCs, enhancing atherosclerosis.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2017-01-01 and is currently open access. It has received 81 citations till now. The article focuses on the topics: Lipofectamine & Proinflammatory cytokine.read more
Citations
More filters
Journal ArticleDOI
Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies.
Xinyu Yang,Xinyu Yang,Yang Li,Yanda Li,Xiaomeng Ren,Xiaomeng Ren,Xiaoyu Zhang,Dan Hu,Yonghong Gao,Yanwei Xing,Hongcai Shang +10 more
TL;DR: Inflammation, mitochondria, autophagy, apoptosis, and epigenetics are discussed as they induce oxidative stress in atherosclerosis, as well as various treatments for antioxidative stress that may prevent Atherosclerosis.
Book ChapterDOI
ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS).
Manuela Kellner,Satish Noonepalle,Qing Lu,Anup Srivastava,Evgeny A. Zemskov,Stephen M. Black +5 more
TL;DR: This chapter focuses on the role played by ROS during the development of ALI/ARDS, the origins of ROS within the cell, cellular defense mechanisms against oxidative damage, the role of ROS in theDevelopment of endothelial permeability, and potential therapies targeted at oxidative stress.
Journal ArticleDOI
Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress.
María Dolores Mauricio,Solanye Guerra-Ojeda,Patricia Marchio,Soraya L. Valles,Martin Aldasoro,Irene Escribano-Lopez,José Raúl Herance,Milagros Rocha,Jose Mª Vila,Victor M. Victor +9 more
TL;DR: The types of nanoparticles according to their chemical composition and the general characteristics of their use in medicine are summarized and nanoparticles with antioxidant properties may improve vascular dysfunction associated with hypertension, diabetes mellitus, or atherosclerosis.
Journal Article
Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes
TL;DR: In this paper, the role of Nox4 in mediating oxidative stress and growth/death in the heart was elucidated, which was accompanied by increased apoptosis and fibrosis at 13 to 14 months of age.
Journal ArticleDOI
NADPH Oxidases and Mitochondria in Vascular Senescence
TL;DR: This review focuses on the role of the mitochondria and the nicotinamide adenine dinucleotide phosphate (NADPH) oxidases Nox1 and Nox4 in vascular senescence, and their contribution to the development of atherosclerosis.
References
More filters
Journal ArticleDOI
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Karen Bedard,Karl-Heinz Krause +1 more
TL;DR: This review summarizes the current state of knowledge of the functions of NOX enzymes in physiology and pathology.
Journal ArticleDOI
Oxidative Stress, Inflammation, and Cancer: How Are They Linked?
TL;DR: Observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.
Journal ArticleDOI
Transforming growth factor-beta induces development of the T(H)17 lineage.
Paul R. Mangan,Laurie E. Harrington,Darrell B. O'Quinn,Whitney S. Helms,Daniel C. Bullard,Charles O. Elson,Robin D. Hatton,Sharon M. Wahl,Trenton R. Schoeb,Casey T. Weaver +9 more
TL;DR: This article identified transforming growth factor-beta (TGF-beta) as a cytokine critical for commitment to Thelper-17 (T(H)17) development, which is required for host protection against a bacterial pathogen, Citrobacter rodentium.
Journal ArticleDOI
Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
TL;DR: A role for cytokine-mediated inflammation in the early stages of atherogenesis is supported in apparently healthy men, and elevated levels of IL-6 are associated with increased risk of future MI.
Journal ArticleDOI
The immune system in atherosclerosis.
TL;DR: Innate as well as adaptive immune responses have been identified in atherosclerosis, with components of cholesterol-carrying low-density lipoprotein triggering inflammation, T cell activation and antibody production during the course of disease.
Related Papers (5)
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Karen Bedard,Karl-Heinz Krause +1 more