Journal ArticleDOI
Nanogap-engineerable Raman-active nanodumbbells for single-molecule detection
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TLDR
Atomic-force-microscope-correlated nano-Raman measurements of individual dumbbell structures demonstrate that Raman signals can be repeatedly detected from single-DNA-tethered nanodumbbells and open avenues for the high-yield synthesis of optically active smart nanoparticles and structurally reproducible nanostructure-based single-molecule detection and bioassays.Abstract:
Surface-enhanced Raman scattering (SERS)-based signal amplification and detection methods using plasmonic nanostructures have been widely investigated for imaging and sensing applications. However, SERS-based molecule detection strategies have not been practically useful because there is no straightforward method to synthesize and characterize highly sensitive SERS-active nanostructures with sufficiently high yield and efficiency, which results in an extremely low cross-section area in Raman sensing. Here, we report a high-yield synthetic method for SERS-active gold-silver core-shell nanodumbbells, where the gap between two nanoparticles and the Raman-dye position and environment can be engineered on the nanoscale. Atomic-force-microscope-correlated nano-Raman measurements of individual dumbbell structures demonstrate that Raman signals can be repeatedly detected from single-DNA-tethered nanodumbbells. These programmed nanostructure fabrication and single-DNA detection strategies open avenues for the high-yield synthesis of optically active smart nanoparticles and structurally reproducible nanostructure-based single-molecule detection and bioassays.read more
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References
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Journal ArticleDOI
Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering
Shuming Nie,Steven R. Emory +1 more
TL;DR: In this article, surface-enhanced Raman scattering was used to detect single molecules and single nanoparticles at room temperature with the use of surface enhanced Raman, and the intrinsic Raman enhancement factors were on the order of 10 14 to 10 15, much larger than the ensemble-averaged values derived from conventional measurements.
Journal ArticleDOI
Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)
Katrin Kneipp,Katrin Kneipp,Yang Wang,Yang Wang,Harald Kneipp,Harald Kneipp,Lev T. Perelman,Lev T. Perelman,Irving Itzkan,Irving Itzkan,Ramachandra R. Dasari,Ramachandra R. Dasari,Michael S. Feld,Michael S. Feld +13 more
TL;DR: In this article, the first observation of single molecule Raman scattering was made using a single crystal violet molecule in aqueous colloidal silver solution using one second collection time and about $2.
Journal ArticleDOI
A DNA-based Method for Rationally Assembling Nanoparticles Into Macroscopic Materials
TL;DR: A method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition is described.
Journal ArticleDOI
Organization of 'nanocrystal molecules' using DNA
A. Paul Alivisatos,A. Paul Alivisatos,Kai Johnsson,Xiaogang Peng,Xiaogang Peng,Troy E. Wilson,Colin J. Loweth,Marcel P. Bruchez,Marcel P. Bruchez,Peter G. Schultz +9 more
TL;DR: A strategy for the synthesis of 'nanocrystal molecules', in which discrete numbers of gold nanocrystals are organized into spatially defined structures based on Watson-Crick base-pairing interactions is described.
Journal ArticleDOI
Surface Enhanced Raman Scattering Enhancement Factors: A Comprehensive Study
TL;DR: In this article, the authors present an in-depth study of surface enhanced Raman scattering (SERS) enhancement factors and cross-sections, including several issues often overlooked, and demonstrate that SERS EFs as low as 107, as opposed to the figure of 1014 often claimed in the literature, are sufficient for SERS applications.
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