Journal ArticleDOI
Natural history of liver fibrosis progression in patients with chronic hepatitis C
TLDR
The host factors of ageing, alcohol consumption, and male sex have a stronger association with fibrosis progression than virological factors in HCV infection.About:
This article is published in The Lancet.The article was published on 1997-03-22. It has received 3008 citations till now. The article focuses on the topics: Hepatitis & Hepatitis C.read more
Citations
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Journal ArticleDOI
Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents
Anthony S. Fauci,John G. Bartlett,Eric P. Goosby,M. D. Smith,H. J. Kaiser,S. W. Chang,James M. Anderson,R. Armstead,A. C. Baker,David A Barr,Samuel A. Bozzette,S. Cox,M. Delaney,Fred M. Gordin,W. Greaves,M. Harrington,J. J. Henning,Martin S. Hirsch,J. Jacobs,Richard Marlink,C. Maxwell,J. W. Mellors,D. B. Nash,S. Perryman,Robert T. Schooley,R. Sherer,Stephen A. Spector,G. Torres,Paul A. Volberding,B. A. Brady,E. M. Daniels,D. Feigal,Mark B. Feinberg,H. D. Gayle,T. R. Graydon,Jonathan E. Kaplan,Abe M. Macher,R. F. Martin,Henry Masur,Lynne M. Mofenson,J. Murray,J. O'Neill,L. C. Perez,R. Riseberg,S. Shekar,Sharilyn K. Stanley,J. Whitescarver +46 more
TL;DR: These Guidelines were developed by the Panel* on Clinical Practices for Treatment of HIV Infection convened by the Department of Health and Human Services and the Henry J. Kaiser Family Foundation.
Journal ArticleDOI
Diagnosis, management, and treatment of hepatitis C: An update
TL;DR: This document has been approved by the AASLD, the Infectious Diseases Society of America, and the American College of Gastroenterology.
Journal ArticleDOI
Hepatitis C Virus Infection
Georg M. Lauer,Bruce D. Walker +1 more
TL;DR: The institution of blood-screening measures in developed countries has decreased the risk of transfusion-associated hepatitis to a negligible level, but new cases continue to occur mainly as a result of injection-drug use and, to a lesser degree, through other means of percutaneous or mucous-membrane exposure.
Journal ArticleDOI
Global epidemiology of hepatitis C virus infection
TL;DR: Because there is no vaccine and no post-exposure prophylaxis for HCV, the focus of primary prevention efforts should be safer blood supply in the developing world, safe injection practices in health care and other settings, and decreasing the number of people who initiate injection drug use.
Journal ArticleDOI
Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IHIT)
Thierry Poynard,Patrick Marcellin,Samuel S. Lee,Christian Niederau,Gerald S. Minuk,Gaetano Ideo,Vincent G. Bain,Jenny Heathcote,Stefan Zeuzem,Christian Trepo,Janice K. Albrecht +10 more
TL;DR: AnInterferon α2b plus ribavirin combination is more effective than 48 weeks of interferonα2b monotherapy and has an acceptable safety profile and patients with few favourable factors benefit more from extending the duration of combination therapy to 48 weeks.
References
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Journal ArticleDOI
An algorithm for the grading of activity in chronic hepatitis C
Pierre Bedossa,Thierry Poynard +1 more
TL;DR: A simple algorithm that generates a single activity score based on basic pathological features in chronic hepatitis C is proposed and tested, showing its accuracy is as high as that obtained using a statistical approach.
Journal ArticleDOI
Classification of chronic hepatitis: diagnosis, grading and staging.
TL;DR: Recombinant human alpha-interferon in patients with chronic nonA-nonB hepatitis and factors predictive of response to interferon alpha therapy in HCV infection are studied.
Journal ArticleDOI
Intraobserver and Interobserver Variations in Liver Biopsy Interpretation in Patients with Chronic Hepatitis C
TL;DR: It is revealed that certain features of major importance in assessing disease activity show significant observer variation, including the acceptable degree of concordance of the Knodell index, whereas other numerical items displayed substantial observer variations.
Journal ArticleDOI
Interrelationship of blood transfusion, non‐A, non‐B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus
Kendo Kiyosawa,Takeshi Sodeyama,Eiji Tanaka,Yukio Gibo,Kaname Yoshizawa,Yoshiyuki Nakano,Seiichi Furuta,Yoshihiro Akahane,Kusuya Nishioka,Robert H. Purcell,Harvey J. Alter +10 more
TL;DR: The slow, sequential progression from acute hepatitis C virus—related non‐A, non‐B hepatitis through chronic hepatitis and cirrhosis to hepatocellular carcinoma is suggested to support a causal association between hepatitis Cirus and hepato Cell carcinoma.
Journal ArticleDOI
Clinical Outcomes after Transfusion-Associated Hepatitis C
TL;DR: In a group of patients seen at a referral center, chronic post-transfusion hepatitis C was a progressive disease and, in some patients, led to death from either liver failure or hepatocellular carcinoma.
Related Papers (5)
An algorithm for the grading of activity in chronic hepatitis C
Pierre Bedossa,Thierry Poynard +1 more