NET Blood Transcript Analysis Defines the Crossing of the Clinical Rubicon: When Stable Disease Becomes Progressive
TLDR
The NETest has predictive and prognostic utility for GEP-NETs identifying clinically actionable alterations ∼1 year before image-based evidence of progression in a long-term follow-up study.Abstract:
Background/Aims: A key issue in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is early identification and prediction of disease progression. Clinical evread more
Citations
More filters
Journal ArticleDOI
Chromogranin A as circulating marker for diagnosis and management of neuroendocrine neoplasms: more flaws than fame
Vincenzo Marotta,Maria Chiara Zatelli,Concetta Sciammarella,Maria Rosaria Ambrosio,Marta Bondanelli,Annamaria Colao,Antongiulio Faggiano +6 more
TL;DR: Current knowledge about the role of the marker for the definition of treatment strategy is poor and is limited by the small number of available studies, their prevalent retrospective nature and the absence of control groups of untreated subjects.
Journal ArticleDOI
The NETest: The Clinical Utility of Multigene Blood Analysis in the Diagnosis and Management of Neuroendocrine Tumors.
Irvin M. Modlin,Mark Kidd,Anna Malczewska,Ignat Drozdov,Lisa Bodei,Somer Matar,Kyung-Min Chung +6 more
TL;DR: The neuroendocrine neoplasms test (NETest) is a multianalyte liquid biopsy that measures neuro endocrine tumor gene expression in blood that meets the 3 critical requirements of an optimal biomarker: diagnostic accuracy, prognostic value, and predictive therapeutic assessment.
Journal ArticleDOI
Role of biomarker tests for diagnosis of neuroendocrine tumours
TL;DR: The diagnosis of gastroenteropancreatic neuroendocrine tumours (NETs) should be made by histological evaluation of tumour tissue, as the diagnostic accuracy of current circulating and imaging biomarkers is insufficient.
Journal ArticleDOI
Current Concepts in 68Ga-DOTATATE Imaging of Neuroendocrine Neoplasms: Interpretation, Biodistribution, Dosimetry, and Molecular Strategies
TL;DR: The role of 68Ga-DOTATATE PET/CT in the diagnostic algorithm of neuroendocrine neoplasms and its overall utility in their management are described.
Journal ArticleDOI
A meta-analysis of the accuracy of a neuroendocrine tumor mRNA genomic biomarker (NETest) in blood.
Kjell Öberg,Andrea Califano,J. Strosberg,Steven Ma,Ulrich-Frank Pape,Lisa Bodei,Gregory Kaltsas,Christos Toumpanakis,James R. Goldenring,Andrea Frilling,S. Paulson +10 more
TL;DR: The meta-analysis supports the utility of the NETest as an IVD to establish a diagnosis and monitor therapeutic efficacy and provides information relevant to NET management consistent with observations regarding utility of liquid biopsies in other oncological disciplines.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
Elizabeth Eisenhauer,P. Therasse,Jan Bogaerts,Lawrence H. Schwartz,Daniel J. Sargent,Robert Ford,Janet Dancey,S. Arbuck,S. Gwyther,Margaret M. Mooney,Larry Rubinstein,Lalitha K. Shankar,Lori E. Dodd,Robert M. Kaplan,Denis Lacombe,Jaap Verweij +15 more
TL;DR: The revised RECIST includes a new imaging appendix with updated recommendations on the optimal anatomical assessment of lesions, and a section on detection of new lesions, including the interpretation of FDG-PET scan assessment is included.
Journal ArticleDOI
Clustering by Passing Messages Between Data Points
Brendan J. Frey,Delbert Dueck +1 more
TL;DR: A method called “affinity propagation,” which takes as input measures of similarity between pairs of data points, which found clusters with much lower error than other methods, and it did so in less than one-hundredth the amount of time.
Book
WHO Classification of Tumours of the Digestive System
TL;DR: WHO Classification of Tumours of the Digestive System - Libros de Medicina - Gastroenterologia oncologica - 128,25
Journal ArticleDOI
Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value
Laetitia Marisa,Aurélien de Reyniès,Alex Duval,Alex Duval,Janick Selves,Marie Pierre Gaub,Laure Vescovo,Marie-Christine Etienne-Grimaldi,Renaud Schiappa,Dominique Guenot,Mira Ayadi,Sylvain Kirzin,Maurice Chazal,Jean-François Fléjou,Jean-François Fléjou,Daniel Benchimol,Anne Berger,Arnaud Lagarde,Erwan Pencreach,F. Piard,Dominique Elias,Yann Parc,Sylviane Olschwang,Gérard Milano,Pierre Laurent-Puig,Valérie Boige,Valérie Boige +26 more
TL;DR: A new classification of CC into six molecular subtypes that arise through distinct biological pathways that improves the current disease stratification based on clinicopathological variables and common DNA markers is described.