Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism.
TLDR
Analysis of metabolic networks using linear optimization theory allows one to quantify and understand the limitations imposed on the cell by its metabolic stoichiometry, and to understand how the flux through each pathway influences the overall behavior of metabolism.About:
This article is published in Journal of Theoretical Biology.The article was published on 1992-02-21 and is currently open access. It has received 255 citations till now.read more
Citations
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Journal ArticleDOI
pH and base counterion affect succinate production in dual-phase Escherichia coli fermentations
TL;DR: Two-phase fermentations using a defined medium at several controlled levels of pH were conducted in Escherichia coli AFP111, which contains mutations in pyruvate formate lyase, lactate dehydrogenase and the phosphotransferase system glucosephosphotranferase enzyme II.
Journal ArticleDOI
Optimization of biochemical systems by linear programming and general mass action model representations
TL;DR: GMA-IOM, based on the separation of the stoichiometric and kinetic aspects of the system, follows the general approach used in the previously presented indirect optimization method (IOM), and makes use of the generalized mass action as the model system representation form.
Book ChapterDOI
Computational modeling of mitochondrial function.
Sonia Cortassa,Miguel A. Aon +1 more
TL;DR: This work outlines the methods, step-by-step, that should be followed to build a computational model of mitochondrial energetics in isolation or integrated to a network of cellular processes.
Book ChapterDOI
Production Processes for Monoclonal Antibodies
Lucas Silva Carvalho,Otávio Bravim da Silva,Gabriela Carneiro deAlmeida,Juliana Davies de Oliveira,Nádia Skorupa Parachin,Talita Souza Carmo +5 more
TL;DR: Largescale production has revolutionized the market for monoclonal antibodies by boosting its production and becoming a more practical method of production.
Journal ArticleDOI
Metabolic states following accumulation of intracellular aggregates: implications for neurodegenerative diseases.
TL;DR: This work proposes a “metabolic cell death by overcrowding” as an alternative hypothesis for the formation of intracellular aggregates and predicts a decrease in the maximum neuronal capacity for energy generation with increasing the concentration of protein aggregates.
References
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Book
Linear and nonlinear programming
David G. Luenberger,Yinyu Ye +1 more
TL;DR: Strodiot and Zentralblatt as discussed by the authors introduced the concept of unconstrained optimization, which is a generalization of linear programming, and showed that it is possible to obtain convergence properties for both standard and accelerated steepest descent methods.
Journal ArticleDOI
The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme.
R W Moreadith,A L Lehninger +1 more
TL;DR: Analysis of oxidative pathways of glutamine and glutamate showed that extramitochondrial malate is oxidized almost quantitatively to pyruvate + CO2 by NAD(P)+-linked malic enzyme, present in the mitochondria of all tumors tested, but absent in heart, liver, and kidney mitochondria.