NeuN/Fox-3 is an intrinsic component of the neuronal nuclear matrix.
TLDR
Fox‐3 and Splicing factor SC35 colocalize by fluorescence microscopy and are repored as uniprotkb-Q6PDU1 and B7ZC13, respectively.About:
This article is published in FEBS Letters.The article was published on 2010-07-02 and is currently open access. It has received 61 citations till now. The article focuses on the topics: NeuN.read more
Citations
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Journal ArticleDOI
NeuN As a Neuronal Nuclear Antigen and Neuron Differentiation Marker.
V V Gusel'nikova,D E Korzhevskiy +1 more
TL;DR: The applica-tion field of immunocytochemical detection of NeuN in scientific and clinical studies, as well as the difficulties in the interpretation of the obtained experimental data and their possible causes, are described in details.
Journal ArticleDOI
Astrocytic abnormalities and global DNA methylation patterns in depression and suicide.
Corina Nagy,Matthew Suderman,Jennie Yang,Moshe Szyf,Naguib Mechawar,Carl Ernst,Gustavo Turecki +6 more
TL;DR: Two-stage data indicate significant differences in the methylation patterns specific to astrocytic dysfunction associated with depressive psychopathology, providing a potential framework for better understanding this disease phenotype.
Journal ArticleDOI
Novel Insights into NeuN: from Neuronal Marker to Splicing Regulator.
TL;DR: This review summarizes the current progress on the biochemical identity and biological significance of NeuN and recommends caution when applying Neu N immunoreactivity as a definitive marker of mature neurons in certain diseases and specific physiological states.
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Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice.
Wilma Helena de Oliveira,Ana Karolina Santana Nunes,Maria Eduarda Rocha de França,Laise Aline Martins dos Santos,Deniele Bezerra Lós,Sura Wanessa Santos Rocha,Karla Patricia de Souza Barbosa,Gabriel Barros Rodrigues,Christina Alves Peixoto +8 more
TL;DR: It is shown that metformin can significantly reduce neuroinflammation and can decrease the loss of neurons in the hippocampus of diabetic animals, which can subsequently promote improvements in spatial memory.
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Splicing Activation by Rbfox Requires Self-Aggregation through Its Tyrosine-Rich Domain
TL;DR: It is found that assembly of the Rbfox CTD plays an essential role in its normal splicing function, and alternative splicing choices also depend on the higher-order assembly of these regulators within the nucleus.
References
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Journal ArticleDOI
NeuN, a neuronal specific nuclear protein in vertebrates.
R.J. Mullen,C.R. Buck,A.M. Smith +2 more
TL;DR: The expression of NeuN is observed in most neuronal cell types throughout the nervous system of adult mice, but some major cell types appear devoid of immunoreactivity including cerebellar Purkinje cells, olfactory bulb mitral cells, and retinal photoreceptor cells.
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Nuclear speckles: a model for nuclear organelles.
Angus I. Lamond,David L. Spector +1 more
TL;DR: Speckles are subnuclear structures that are enriched in pre-messenger RNA splicing factors and are located in the interchromatin regions of the nucleoplasm of mammalian cells, and can cycle continuously between speckles and other nuclear locations, including active transcription sites.
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The Organization of Replication and Transcription
TL;DR: An alternative model in which DNA and RNA polymerases are immobilized by attachment to larger structures, where they reel in their templates and extrude newly made nucleic acids is supported.
Journal ArticleDOI
Variation in alternative splicing across human tissues
TL;DR: This study distinguishes the human brain, testis and liver as having unusually high levels of AS, highlights differences in the types of AS occurring commonly in different tissues, and identifies candidate cis-regulatory elements and trans-acting factors likely to have important roles in tissue-specific AS in human cells.
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In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction
TL;DR: DNA topoisomerase II has been immunochemically identified on protein blots as a major polypeptide component of the Drosophila nuclear matrix-pore complex-lamina fraction and upon nuclear disassembly during mitosis appears to redistribute diffusely throughout the cell.