Journal ArticleDOI
New Coumarin-Pyrazole hybrids: Synthesis, Docking studies and Biological evaluation as potential cholinesterase inhibitors
Amina Benazzouz-Touami,xiang zheng,Amina Chouh,Sabrina Halit,Souhila Terrachet-Bouaziz,Malika Makhloufi-Chebli,Karima Ighil-Ahriz,Artur M. S. Silva +7 more
TLDR
In vitro studies showed that compounds 3e and 3f were the most effective showing high potential AChE inhibitory activities with respective IC50 values, and in silico predictions of toxicity analysis indicated that these compounds should have good oral bioavailability.About:
This article is published in Journal of Molecular Structure.The article was published on 2022-02-05. It has received 13 citations till now. The article focuses on the topics: Chemistry & Butyrylcholinesterase.read more
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Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and pyridazines based isoxazole
Hyam A. Radwan,Iqrar Ahmad,Ismail M.M. Othman,Mohamed A. M. Gad-Elkareem,Harun M. Patel,Kais Aouadi,Mejdi Snoussi,Adel Kadri +7 more
TL;DR: In this article , a series of pyrazoles, triazoles and pyridazines based isoxazole were synthesized, and well characterized, and the properties of these compounds were evaluated.
Journal ArticleDOI
“Pyrazolo-Imidazolidinones: Synthesis, Antimicrobial Assessment and Molecular Modelling Studies by Molecular Mechanic and Quantum Mechanic Approach”
Nisheeth C. Desai,Surbhi B. Joshi,Ashvinkumar G. Khasiya,Dharmpalsinh J. Jadeja,H K Mehta,Medha Pandya,Iqrar Ahmad,Harun M. Patel +7 more
TL;DR: In this paper , a set of fifteen pyrazole-imidazolidinone hybrids were synthesized and tested for antimicrobial activity, and the results showed that the compounds 4f with MIC (Minimum Inhibitory Concentration) 12.5 μg/mL against A. clavatus and 4l with MIC 12.6 μg /mL against P. aeruginosa were the most active compared to the standard drugs.
Journal ArticleDOI
Diverse and efficient catalytic applications of new cockscomb flower-like Fe3O4@SiO2@KCC-1@MPTMS@CuII mesoporous nanocomposite in the environmentally benign reduction and reductive acetylation of nitroarenes and one-pot synthesis of some coumarin compounds
TL;DR: In this paper , a new cockscomb flower-like mesoporous nanocomposite was prepared and characterized by various techniques including Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), SEM-based energy-dispersive X -ray (EDX) spectrography, inductively coupled plasma-optical emission spectrometry (ICP-OES), thermogravimetric analysis/differential thermal analysis (TGA/DTA), vibrating sample magnetometry (VSM), UV-Vis spectroscope, and Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halenda (BJH) analyses.
Journal ArticleDOI
Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties
Nehmedo G. Fawazy,Siva S. Panda,Ahmed Mostafa,Benson M. Kariuki,Mohamed S. Bekheit,Yassmin Moatasim,Omnia Kutkat,Walid Fayad,May A. El-Manawaty,Ahmed A. Soliman,Riham A. El-Shiekh,Aladdin M. Srour,Reham F. Barghash,Adel S. Girgis +13 more
TL;DR: In this paper , a series of 1-alkylsulfonyl dispiro[indoline-3,2'-pyrrolidine-3',3″-piperidine]-2,4″-diones 6a'o has been synthesized through regioselective multi-component azomethine dipolar cycloaddition reaction of 1-(alkyl sulfonyls)-3,5-bis(ylidene)-piperidin-4-ones 3a'h. X-ray diffraction studies (6b'd,h) confirmed the structures.
Journal ArticleDOI
Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties
Nehmedo G. Fawazy,Siva S. Panda,Ahmed Mostafa,Benson M. Kariuki,Mohamed S. Bekheit,Yassmin Moatasim,Omnia Kutkat,Walid Fayad,May A. El-Manawaty,Ahmed A. Soliman,Riham A. El-Shiekh,Aladdin M. Srour,Reham F. Barghash,Adel S. Girgis +13 more
TL;DR: In this article , a series of 1-alkylsulfonyl dispiro[indoline-3,2'-pyrrolidine-3',3″-piperidine]-2,4″-diones 6a'o has been synthesized through regioselective multi-component azomethine dipolar cycloaddition reaction of 1-(alkyl sulfonyls)-3,5-bis(ylidene)-piperidin-4-ones 3a'h. X-ray diffraction studies (6b'd,h) confirmed the structures.
References
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Molecular docking studies on the interaction of NCI anticancer analogues with human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
David Ebuka Arthur,Adamu Uzairu +1 more
TL;DR: In this paper, 119 NCI anticancer compounds on lipid kinase P13K-gamma (4FA6) were screened in order to identify chemical agent that best inhibits P13k-Gamma a class IB phosphoinositide which is a pro-survival signaling pathway critical in the development of cancer in white blood cells.
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Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies.
Hüseyin Çavdar,Murat Şentürk,Murat Güney,Serdar Durdagi,Gülru Kayık,Claudiu T. Supuran,Deniz Ekinci +6 more
TL;DR: Being diverse of the classical AChE and BuChE inhibitors, the investigated uracil derivatives may be used as lead molecules for designing new therapeutically effective enzyme inhibitors.
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Coumarin–triazole Hybrids and Their Biological Activities
Yi-Lei Fan,Xing Ke,Min Liu +2 more
TL;DR: This review aims to outline the biological activities of coumarin–triazole hybrids, and discuss their structure–activity relationship to pave the way for the further rational development of this kind of hybrids.
Journal ArticleDOI
A Computational Study on the Acidity Dependence of Radical-Scavenging Mechanisms of Anthocyanidins
TL;DR: In this paper, the authors analyzed the radical-scavenging property attributed to anthocyanidins considering three mechanisms: hydrogen atom transfer (HAT), stepwise electron-transfer−proton-transfer (ET−PT), and sequential proton loss electron transfer (SPLET).
Journal ArticleDOI
Coumarin-containing hybrids and their antibacterial activities.
TL;DR: This review outlines the advances in coumarin‐containing hybrids with antibacterial potential in the recent 5 years and the structure–activity relationships are also discussed.