Journal ArticleDOI
New Coumarin-Pyrazole hybrids: Synthesis, Docking studies and Biological evaluation as potential cholinesterase inhibitors
Amina Benazzouz-Touami,xiang zheng,Amina Chouh,Sabrina Halit,Souhila Terrachet-Bouaziz,Malika Makhloufi-Chebli,Karima Ighil-Ahriz,Artur M. S. Silva +7 more
TLDR
In vitro studies showed that compounds 3e and 3f were the most effective showing high potential AChE inhibitory activities with respective IC50 values, and in silico predictions of toxicity analysis indicated that these compounds should have good oral bioavailability.About:
This article is published in Journal of Molecular Structure.The article was published on 2022-02-05. It has received 13 citations till now. The article focuses on the topics: Chemistry & Butyrylcholinesterase.read more
Citations
More filters
Journal ArticleDOI
Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and pyridazines based isoxazole
Hyam A. Radwan,Iqrar Ahmad,Ismail M.M. Othman,Mohamed A. M. Gad-Elkareem,Harun M. Patel,Kais Aouadi,Mejdi Snoussi,Adel Kadri +7 more
TL;DR: In this article , a series of pyrazoles, triazoles and pyridazines based isoxazole were synthesized, and well characterized, and the properties of these compounds were evaluated.
Journal ArticleDOI
“Pyrazolo-Imidazolidinones: Synthesis, Antimicrobial Assessment and Molecular Modelling Studies by Molecular Mechanic and Quantum Mechanic Approach”
Nisheeth C. Desai,Surbhi B. Joshi,Ashvinkumar G. Khasiya,Dharmpalsinh J. Jadeja,H K Mehta,Medha Pandya,Iqrar Ahmad,Harun M. Patel +7 more
TL;DR: In this paper , a set of fifteen pyrazole-imidazolidinone hybrids were synthesized and tested for antimicrobial activity, and the results showed that the compounds 4f with MIC (Minimum Inhibitory Concentration) 12.5 μg/mL against A. clavatus and 4l with MIC 12.6 μg /mL against P. aeruginosa were the most active compared to the standard drugs.
Journal ArticleDOI
Diverse and efficient catalytic applications of new cockscomb flower-like Fe3O4@SiO2@KCC-1@MPTMS@CuII mesoporous nanocomposite in the environmentally benign reduction and reductive acetylation of nitroarenes and one-pot synthesis of some coumarin compounds
TL;DR: In this paper , a new cockscomb flower-like mesoporous nanocomposite was prepared and characterized by various techniques including Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), SEM-based energy-dispersive X -ray (EDX) spectrography, inductively coupled plasma-optical emission spectrometry (ICP-OES), thermogravimetric analysis/differential thermal analysis (TGA/DTA), vibrating sample magnetometry (VSM), UV-Vis spectroscope, and Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halenda (BJH) analyses.
Journal ArticleDOI
Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties
Nehmedo G. Fawazy,Siva S. Panda,Ahmed Mostafa,Benson M. Kariuki,Mohamed S. Bekheit,Yassmin Moatasim,Omnia Kutkat,Walid Fayad,May A. El-Manawaty,Ahmed A. Soliman,Riham A. El-Shiekh,Aladdin M. Srour,Reham F. Barghash,Adel S. Girgis +13 more
TL;DR: In this paper , a series of 1-alkylsulfonyl dispiro[indoline-3,2'-pyrrolidine-3',3″-piperidine]-2,4″-diones 6a'o has been synthesized through regioselective multi-component azomethine dipolar cycloaddition reaction of 1-(alkyl sulfonyls)-3,5-bis(ylidene)-piperidin-4-ones 3a'h. X-ray diffraction studies (6b'd,h) confirmed the structures.
Journal ArticleDOI
Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties
Nehmedo G. Fawazy,Siva S. Panda,Ahmed Mostafa,Benson M. Kariuki,Mohamed S. Bekheit,Yassmin Moatasim,Omnia Kutkat,Walid Fayad,May A. El-Manawaty,Ahmed A. Soliman,Riham A. El-Shiekh,Aladdin M. Srour,Reham F. Barghash,Adel S. Girgis +13 more
TL;DR: In this article , a series of 1-alkylsulfonyl dispiro[indoline-3,2'-pyrrolidine-3',3″-piperidine]-2,4″-diones 6a'o has been synthesized through regioselective multi-component azomethine dipolar cycloaddition reaction of 1-(alkyl sulfonyls)-3,5-bis(ylidene)-piperidin-4-ones 3a'h. X-ray diffraction studies (6b'd,h) confirmed the structures.
References
More filters
Journal ArticleDOI
New diarylheptanoids from the stems of Carpinus cordata.
TL;DR: Two new diarylheptanoids, carpinontriols A and B, were isolated from the stems of Carpinus cordata, along with the known diaryl heptanoid, casuarinondiol, and five known compounds.
Journal ArticleDOI
Theoretical insight into the antioxidative activity of isoflavonoid: The effect of the C2=C3 double bond.
TL;DR: D density functional theory methods were applied to investigate the influence of the C2=C3 double bond on the antioxidative activity of isoflavonoids based on three currently accepted radical scavenging mechanisms from the viewpoint of thermodynamics.
Journal ArticleDOI
Synthesis and biological evaluation of novel pyrazole compounds
Amal M. Youssef,Edward G. Neeland,Erika B. Villanueva,M. Sydney White,Ibrahim M. El-Ashmawy,Brian O. Patrick,Andis Klegeris,Alaa S. Abd-El-Aziz +7 more
TL;DR: A novel dipyrazole ethandiamide compound and acid chloride of pyrazolo[3,4-d]pyrimidine 4(5H)-one were prepared and reacted with a number of nucleophiles and two compounds were notable for their anti-inflammatory activity that was comparable to that of the clinically available cyclooxygenase-2 inhibitor celecoxib.
Journal ArticleDOI
Pyrazole–coumarin and pyrazole–quinoline chalcones as potential antitubercular agents
TL;DR: Two series of novel pyrazole-coumarin chalcones and pyrazoles-quinoline chalCones were synthesized using multiple-step reactions, and these compounds exhibited good pharmacological and oral absorption properties.
Journal ArticleDOI
Green synthesis, antioxidant and antibacterial activities of 4-aryl-3,4-dihydropyrimidinones/thiones derivatives of curcumin. Theoretical calculations and mechanism study
Nassima Khaldi-Khellafi,Malika Makhloufi-Chebli,Djamila Oukacha-Hikem,Souhila Terachet Bouaziz,Kamilia Ould Lamara,Taous Idir,Amina Benazzouz-Touami,Françoise Dumas +7 more
TL;DR: In this article, 3,4-Dihydropyrimidin-2(1H)-one/thione analogs of curcumin were synthesized in good yield by a one-pot multi-component cyclocondensation using Curcumin, substituted aromatic aldehydes, and urea/thiourea in less volume of ethanol catalysed by commercial H3PMo12O40 5% mol as a recyclable and nontoxic catalyst under conventional heating and microwave irradiation.