Journal ArticleDOI
New degradative routes of 5-hydroxytryptophan and serotonin by intestinal tryptophan 2,3-dioxygenase.
Fusao Hirata,Osamu Hayaishi +1 more
TLDR
A highly purified preparation of tryptophan 2,3-dioxygenase from rabbit intestine was found to catalyze the oxygenative ring cleavage of 5-hydroxytryptophan and serotonin, and the products of these enzymic reactions were susceptible to the action of formamidase.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1972-06-09. It has received 106 citations till now. The article focuses on the topics: Tryptophan & 5-Hydroxytryptophan.read more
Citations
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Journal ArticleDOI
Heme-Containing Oxygenases
Journal ArticleDOI
Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines
TL;DR: K is of special interest due to its properties as a potent cyclooxygenase inhibitor, NO scavenger forming a stable nitrosation product, inhibitor and/or downregulator of neuronal and inducible NO synthases, and a mitochondrial metabolism modulator.
Journal ArticleDOI
Indoleamine 2,3-dioxygenase. Purification and some properties.
TL;DR: Indoleamine 2,3-dioxygenase was purified from rabbit small intestine to apparent homogeneity as judged by polyacrylamide gel electrophoresis and analytical ultracentrifugation.
Journal ArticleDOI
Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes
TL;DR: Emphasis is put on the structural features, photophysical behavior, biomolecular interactions, cellular uptake, and intracellular localization properties of luminescent transition metal complexes.
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In Vitro and in Vivo Formation of Two New Metabolites of Melatonin
TL;DR: The results indicate that these two new metabolites are involved in the major metabolic pathway of melatonin in the central nervous system.
References
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Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue
TL;DR: The results are shown to favour the ferryl ion structure, or an isomer of this structure, for the higher oxidation state, and theHigher oxidation state may provisionally be named ferrylmyoglobin.
Journal ArticleDOI
Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism.
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A Rapid Spectrophotometric Assay of Monoamine Oxidase Based on the Rate of Disappearance of Kynuramine
TL;DR: Intramolecular (nonenzymatic) condensation of the aminoaldehyde proved to be faster than the further oxidation of the aldehyde to the acid or lactam and has been developed into a rapid method for the assay of monoamine oxidase.
Journal ArticleDOI
The conversion of tryptophan to kynurenine in liver. I. The coupled tryptophan peroxidase-oxidase system forming formylkynurenine.
W E Knox,Alan H. Mehler +1 more
TL;DR: The over-all reaction to kynurenine is described, and the first two steps are identified as a physiological, coupled oxidation system consisting of a tryptophan peroxidase and an oxidase which forms peroxide.
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Enzymic Studies on the Biosynthesis of Serotonin in Mammalian Brain
TL;DR: Tryptophan 5-monooxygenase activity is detected in both the soluble and particulate fractions from the guinea pig brain stem and the radioactive CO2 evolved is almost entirely accounted for by the formation of serotonin-14C.
Related Papers (5)
Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes.
Shozo Yamamoto,Osamu Hayaishi +1 more