New insights into meticillin-resistant Staphylococcus aureus (MRSA) pathogenesis, treatment and resistance
Ian M. Gould,Michael Z. David,Silvano Esposito,Javier Garau,Gerard Lina,Teresita Mazzei,Georg Peters +6 more
TLDR
Recent pre-clinical data support a species-specific role for Panton-Valentine leukocidin in the development of acute severe S. aureus infections and elucidated other virulence mechanisms, including novel modes of internalisation, varying post-invasion strategies (featuring both upregulation and downregulation of virulence factors) and phenotypic switching.About:
This article is published in International Journal of Antimicrobial Agents.The article was published on 2013-06-01 and is currently open access. It has received 280 citations till now. The article focuses on the topics: Telavancin & Tigecycline.read more
Citations
More filters
Journal ArticleDOI
Methicillin-resistant Staphylococcus aureus.
Andie S Lee,Andie S Lee,Hermínia de Lencastre,Hermínia de Lencastre,Javier Garau,Jan Kluytmans,Surbhi Malhotra-Kumar,Andreas Peschel,Stéphan Juergen Harbarth +8 more
TL;DR: The success of MRSA is a consequence of the extensive arsenal of virulence factors produced by S. aureus combined with β-lactam resistance and, for most clones, resistance to other antibiotic classes as discussed by the authors.
Journal ArticleDOI
Mechanisms of Methicillin Resistance in Staphylococcus aureus
TL;DR: Many of the molecular and biochemical mechanisms underlying methicillin resistance in S. aureus have been elucidated, including regulatory events and the structure of key proteins, and recent advances are reviewed.
Journal ArticleDOI
Incidence, prevalence, and management of MRSA bacteremia across patient populations-a review of recent developments in MRSA management and treatment.
TL;DR: Trends in epidemiology and factors that influence the incidence of MRSA bacteremia are described and current and developing diagnostic tools, treatments, and prevention strategies are discussed.
Journal ArticleDOI
Methicillin-Resistant Staphylococcus aureus Therapy: Past, Present, and Future
TL;DR: Linezolid is recommended for PO or IV treatment of skin and skin structure infections (SSSIs) and pneumonia caused by MRSA and several investigational agents with activity against drug-resistant gram-positive pathogens are being developed primarily for treatment of MRSA infections, including tedizolid, dalbavancin, and oritavancein.
Journal ArticleDOI
Staphylococcus aureus virulence factors in evasion from innate immune defenses in human and animal diseases
Alfonso Zecconi,Federico Scali +1 more
TL;DR: This review focused on S. aureus virulence factors involved in the immune evasion in the first phases of infection: TLR recognition avoidance, adhesins affecting immune response and resistance to host defenses peptides and polypeptides.
References
More filters
Journal ArticleDOI
Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children
Catherine Liu,Arnold S. Bayer,Sara E. Cosgrove,Robert S. Daum,Scott K. Fridkin,Rachel J. Gorwitz,Sheldon L. Kaplan,Adolf W. Karchmer,Donald P. Levine,Barbara E. Murray,Michael J. Rybak,Henry F. Chambers +11 more
TL;DR: These guidelines discuss the management of a variety of clinical syndromes associated with MRSA disease, including skin and soft tissue infections (SSTI), bacteremia and endocarditis, pneumonia, bone and joint infections, and central nervous system infections.
Journal ArticleDOI
Involvement of Panton-Valentine Leukocidin—Producing Staphylococcus aureus in Primary Skin Infections and Pneumonia
Gerard Lina,Yves Piémont,Florence Godail-Gamot,Michèle Bes,Marie Odile Peter,Valérie Gauduchon,François Vandenesch,Jerome Etienne +7 more
TL;DR: Panton-Valentine leukocidin genes were detected in 93% of strains associated with furunculosis and in 85% of those associated with severe necrotic hemorrhagic pneumonia (all community-acquired), and it appears that PVL is mainly associated with nec rotic lesions involving the skin or mucosa.
Journal ArticleDOI
Comparison of mortality associated with methicillin-resistant and methicillin-susceptible staphylococcus aureus bacteremia: A meta-analysis
Sara E. Cosgrove,George Sakoulas,Eli N. Perencevich,Mitchell J. Schwaber,Adolf W. Karchmer,Yehuda Carmeli,Yehuda Carmeli +6 more
TL;DR: A meta-analysis was performed to summarize the impact of methicillin-resistance on mortality in Staphylococcus aureus bacteremia and explored the reasons for heterogeneity by means of subgroup analyses.
Journal ArticleDOI
Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic.
Michael Z. David,Robert S. Daum +1 more
TL;DR: This review details the epidemiology of CA-MRSA strains and the clinical spectrum of infectious syndromes associated with them that ranges from a commensal state to severe, overwhelming infection and addresses the therapy of these infections and strategies for their prevention.