Journal ArticleDOI
NLRP3 inflammasome activation and oxidative stress status in the mild and moderate SARS-CoV-2 infected patients: impact of melatonin as a medicinal supplement.
Hadi Esmaeili Gouvarchin Ghaleh,Abdolkarim Hosseini,Hossein Aghamollaei,Mahdi Fasihi-Ramandi,Gholam Hossein Alishiri,Ali Saeedi-Boroujeni,Kazem Hassanpour,Mohammad-Reza Mahmoudian-Sani,Gholamreza Farnoosh +8 more
TLDR
In this article, the impacts of melatonin as complementary treatments on oxidative stress agents and inflammasome activation in patients with COVID-19 patients were assessed and it was found that melatonin can be effective as a medicinal supplement in decreasing the inflammaome multiprotein complex and oxidative stress along with beneficial impacts on lung cytokine storm of COVID19 patients.Abstract:
The inflammasome as a multiprotein complex has a role in activating ASC and caspase-1 resulting in activating IL-1s in various infections and diseases like corona virus infection in various tissues. It was shown that these tissues are affected by COVID-19 patients. According to the current evidence, melatonin is not veridical while possessing a high safety profile, however, it possesses indirect anti-viral actions owing to its anti-oxidation, anti-inflammation, and immune improving properties. This study aims to assess the impacts of melatonin as the complementary treatments on oxidative stress agents and inflammasome activation in patients with COVID-19. Melatonin supplement (9 mg daily, orally) was provided for the patients hospitalized with a COVID-19 analysis for 14 days. For measuring IL-10, IL-1s, and TNF-α cytokines and malondialdehyde (MDA), nitric oxide (NO), and superoxide dismutase (SOD) level and the expression of CASP1 and ASC genes, blood samples were gathered from the individuals at the start and termination of the therapy. Our findings indicated that melatonin is used as a complementary treatment to reduce the levels of TNF-α and IL-1s cytokines, MDA, and NO levels in COVID-19 patients and significantly increase SOD level, however, the levels of IL-10 cytokine possesses no considerable changes. The findings revealed that genes of CASP1 and ASC were dysregulated by melatonin regulating the inflammasome complex. Based on the findings of the current study, it is found that melatonin can be effective as a medicinal supplement in decreasing the inflammasome multiprotein complex and oxidative stress along with beneficial impacts on lung cytokine storm of COVID-19 patients.read more
Citations
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Journal ArticleDOI
Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection
Russel J. Reiter,Ramaswamy Sharma,Fedor Simko,Alberto Dominguez-Rodriguez,Jan Tesarik,Richard L. Neel,Andrzej Slominski,Konrad Kleszczyński,Verna M Martin-Gimenez,Walter Manucha,Daniel P. Cardinali +10 more
TL;DR: Melatonin has pan-antiviral effects and it diminishes the severity of viral infections and reduces the death of animals infected with numerous different viruses, including three different coronaviruses as discussed by the authors .
Journal ArticleDOI
Potential benefits of ginseng against COVID-19 by targeting inflammasomes
TL;DR: Wang et al. as discussed by the authors discussed the potential preventive and therapeutic roles of ginseng in COVID-19 based on its regulatory role in inflammasome initiation and the host's antiviral immunity.
Journal ArticleDOI
Sunlight Exposure and Phototherapy: Perspectives for Healthy Aging in an Era of COVID-19.
Toshiaki Nakano,Toshiaki Nakano,Kuei-Chen Chiang,Kuei-Chen Chiang,Chien-Chih Chen,Po-Jung Chen,Chia-Yun Lai,Li-Wen Hsu,Li-Wen Hsu,Naoya Ohmori,Takeshi Goto,Chao-Long Chen,Shigeru Goto,Shigeru Goto +13 more
TL;DR: In this paper, the potential mechanisms and clinical value of phototherapy with a full spectrum light (notably blue, red, and near-infrared light) as an alternative to sunlight exposure, which may contribute to combating COVID-19 and promoting active and healthy aging in current aged/superaged societies.
Journal ArticleDOI
The role of melatonin as an adjuvant in the treatment of COVID-19: A systematic review
TL;DR: Wang et al. as mentioned in this paper summarized the clinical studies on the effects of melatonin on Coronavirus disease 2019 patients and highlighted the probable role of Melatonin as a potential adjuvant in the treatment of COVID-19.
Journal ArticleDOI
COVID-19 in G6PD-deficient patients, oxidative stress, and neuropathology.
Beatriz Hernández-Ochoa,Daniel Ortega-Cuellar,Abigail González-Valdez,Noemí Cárdenas-Rodríguez,Julieta G. Mendoza-Torreblanca,Itzel Jatziri Contreras-García,Luz Adriana Pichardo-Macías,Cindy Bandala,Saúl Gómez-Manzo +8 more
TL;DR: The evidence of the role of G6PD in COVID-19 and its possible role in the generation of oxidative stress and glucose metabolism deficits and inflammation present in this respiratory disease and its progression including neurological manifestations is summarized.
References
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Journal ArticleDOI
Melatonin: Pharmacology, Functions and Therapeutic Benefits
Sylvie Tordjman,Sylvie Chokron,Richard Delorme,Annaëlle Charrier,Eric Bellissant,Nemat Jaafari,Claire Fougerou +6 more
TL;DR: This review highlights the high number and diversity of major melatonin effects and opens important perspectives for measuring melatonin as a biomarker (biomarker of early identification of certain disorders and also biomarker of their follow-up) and using melatonin with clinical preventive and therapeutic applications in newborns, children and adults based on its physiological regulatory effects.
Journal ArticleDOI
Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue
TL;DR: It is demonstrated that melatonin alleviates inflammasome‐induced pyroptosis by blocking NF‐κB/GSDMD signal in mice adipose tissue, suggesting a new potential therapy for melatonin to prevent and treat obesity caused systemic inflammatory response.
Journal ArticleDOI
Initial impacts of global risk mitigation measures taken during the combatting of the COVID-19 pandemic.
Yuri Bruinen de Bruin,Anne Sophie Lequarre,Josephine McCourt,Peter Clevestig,Filippo Pigazzani,Maryam Zare Jeddi,Claudio Colosio,Margarida Goulart +7 more
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Journal ArticleDOI
Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome
Yong Zhang,Xiru Li,Jamison J. Grailer,Na Wang,Mingming Wang,Jianfei Yao,Rui Zhong,George F. Gao,Peter A. Ward,Dun Xian Tan,Xiangdong Li +10 more
TL;DR: Intatracheal administration of melatonin markedly reduced the pulmonary injury and decreased the infiltration of macrophages and neutrophils into lung in an LPS‐induced ALI mouse model, and opening a more efficient therapeutic approach for treating ALI.
Journal ArticleDOI
Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation
TL;DR: Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti- inflammatory cytokines in different pathophysiological conditions and its roles and its protective effects against the activation of the inflammasomes and, in particular, of the NLRP3 inflammaome are focused on.