Journal ArticleDOI
Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs.
Mukta Agrawal,Swarnlata Saraf,Shailendra Saraf,Sophia G. Antimisiaris,Mahavir B. Chougule,Sunday A. Shoyele,Amit Alexander +6 more
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TLDR
The latest works on various novel formulations loaded with various anti‐Alzheimer agents are discussed, which underlines the fact that majority of work related to the nose‐to‐brain delivery of anti‐AD drugs is limited only up to preclinical studies.About:
This article is published in Journal of Controlled Release.The article was published on 2018-07-10. It has received 331 citations till now. The article focuses on the topics: Drug delivery & Drug carrier.read more
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Intramuscular desferrioxamine in patients with Alzheimer's disease
TL;DR: In this paper, a single-blind study was conducted to investigate whether the progression of dementia could be slowed by the trivalent ion chelator, desferrioxamine.
Journal ArticleDOI
Strategies for delivering therapeutics across the blood–brain barrier
TL;DR: In this paper, the authors review recent developments and challenges related to selected blood-brain barrier-crossing strategies with a focus on non-invasive approaches such as receptor-mediated transcytosis and the use of neurotropic viruses, nanoparticles and exosomes.
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Chitosan and chitosan coating nanoparticles for the treatment of brain disease.
TL;DR: A comprehensive review on the advantages and recent progresses in the treatment of brain disease by chitosan nanoparticles is given.
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Blood-Brain Delivery Methods Using Nanotechnology
Daniel Mihai Teleanu,Cristina Chircov,Alexandru Mihai Grumezescu,Alexandru Mihai Grumezescu,Adrian Volceanov,Raluca Ioana Teleanu +5 more
TL;DR: The development of nanotechnology-based approaches for brain delivery, such as nanoparticles, liposomes, dendrimers, micelles, and carbon nanotubes, might be the solution for improved brain therapies.
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The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
Dominic M. Walsh,Igor Klyubin,Julia V. Fadeeva,William K. Cullen,Roger Anwyl,Michael S. Wolfe,Michael J. Rowan,Dennis J. Selkoe +7 more
TL;DR: It is reported that natural oligomers of human Aβ are formed soon after generation of the peptide within specific intracellular vesicles and are subsequently secreted from the cell, indicating that synaptotoxic Aβ oligomers can be targeted therapeutically.
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A simple equation for description of solute release II. Fickian and anomalous release from swellable devices
TL;DR: In this paper, an exponential relation M t /M ∞ = kt n may be used to describe the Fickian and non-Fickian release behavior of release systems which are prepared by incorporation of a drug in a hydrophilic, initially glassy polymer.
Journal ArticleDOI
Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
TL;DR: An understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells is presented.