Journal ArticleDOI
Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma.
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TLDR
The metabolite profiles obtained through this dual phase UPLC-MS/MS method are expected to increase the understanding of the role warfarin metabolism plays in patient response to therapy and yield new strategies to improve patient outcomes.About:
This article is published in Journal of Chromatography B.The article was published on 2011-05-01. It has received 39 citations till now. The article focuses on the topics: High-performance liquid chromatography & Liquid chromatography–mass spectrometry.read more
Citations
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Challenges in the development of bioanalytical liquid chromatography–mass spectrometry method with emphasis on fast analysis
TL;DR: Novel and modern approaches in sample preparation, chromatography and detection are especially emphasized, attention is paid to proper calibration approach and matrix effects that can seriously affect method accuracy and precision.
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An electrochemical sensor based on multiwall carbon nanotubes and molecular imprinting strategy for warfarin recognition and determination
TL;DR: In this article, a sensitive electrochemical sensor for warfarin was prepared based on molecular imprinting strategy by electropolymerization qof o-phenylenediamine (o-PD) on a glassy carbon electrode via cyclic voltammetry (CV).
Journal ArticleDOI
Carbonyl reduction pathways in drug metabolism
Petra Malátková,Vladimír Wsól +1 more
TL;DR: This review focuses on drugs that have been reported to be reduced at the carbonyl group in vivo and summarizes the published data in order to thoroughly describe the reductive metabolism of the selected drugs and to demonstrate the role ofcarbonyl reduction in the context of their overall metabolism.
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Computational design of an enantioselective molecular imprinted polymer for the solid phase extraction of S-warfarin from plasma.
TL;DR: An enantioselective molecular imprinted polymer for S-warfarin was designed computationally by using the density functional theory (DFT) at B3LYP/631G+ (d, p) level and Gaussian 2003 package and accurate results were obtained.
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Development of a chiral micellar electrokinetic chromatography–tandem mass spectrometry assay for simultaneous analysis of warfarin and hydroxywarfarin metabolites: Application to the analysis of patients serum samples
TL;DR: The method was successfully applied for the first time to analyze WAR and its metabolites in plasma samples of 55 patients undergoing WAR therapy, demonstrating the potential of chiral MEKC-MS/MS method to accurately quantitate with high sensitivity.
References
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Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
William R. Wikoff,Andrew T. Anfora,Jun Liu,Peter G. Schultz,Scott A. Lesley,Eric C. Peters,Gary Siuzdak +6 more
TL;DR: A broad, drug-like phase II metabolic response of the host to metabolites generated by the microbiome was observed, suggesting that the gut microflora has a direct impact on the drug metabolism capacity of theHost.
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Oral Anticoagulants: Mechanism of Action, Clinical Effectiveness, and Optimal Therapeutic Range
Jack Hirsh,James E. Dalen,David Anderson,Leon Poller,Henry I. Bussey,Jack Ansell,Daniel Deykin +6 more
TL;DR: The mainstay treatment for atrial fibrillation is Coumadin Aspirin Reinfarction, but the use of aspirin for other reasons is also being considered.
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Human P450 metabolism of warfarin.
TL;DR: The anticoagulant drug warfarin occurs as a pair of enantiomers that are differentially metabolized by human cytochromes P450 (CYP) and is affected primarily when metabolism of S-warfarin is altered.
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Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.
Allan E. Rettie,Kenneth R. Korzekwa,Kent L. Kunze,R F Lawrence,A C Eddy,Toshifumi Aoyama,Harry V. Gelboin,Frank J. Gonzalez,William F. Trager +8 more
TL;DR: It is concluded that 2C9 is likely to be a principal form of human liver P-450 which modulates the in vivo anticoagulant activity of the drug.
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Cardiology patient pages. the surgeon general’s call to action to prevent deep vein thrombosis and pulmonary embolism
TL;DR: On September 15, 2008, the US Surgeon General, Rear Admiral Steven K. Galson, MD, MPH, issued the first Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism, collectively known as venous thromboembolism (VTE).