Novel targets for positron emission tomography (PET) radiopharmaceutical tracers for visualization of neuroinflammation
I. A. Shchepetkin,I. A. Shchepetkin,Maria Shvedova,Maria Shvedova,Yana Anfinogenova,M Litvak,M Litvak,Dmitriy N. Atochin,Dmitriy N. Atochin,Dmitriy N. Atochin +9 more
- Vol. 886, Iss: 1, pp 012015
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TLDR
The review summarizes the developments of various radiolabeled ligands for PET imaging of neuroinflammation, based on detection of isotope labeled tracers, which emit positrons.Abstract:
Non-invasive molecular imaging techniques can enhance diagnosis of neurological diseases to achieve their successful treatment. Positron emission tomography (PET) imaging can identify activated microglia and provide detailed functional information based on molecular biology. This imaging modality is based on detection of isotope labeled tracers, which emit positrons. The review summarizes the developments of various radiolabeled ligands for PET imaging of neuroinflammation.read more
Citations
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Research on system response matrix modelling method of rectangular PET scanner based on Monte Carlo simulation
TL;DR: In this article, the authors proposed a method based on system geometric symmetry to reduce the simulation time and split the symmetry into two types: intra-ring symmetry and inter-axis symmetry, a total of 208 times the symmetry is used.
References
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Journal ArticleDOI
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
TL;DR: This review focuses on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain.
Journal ArticleDOI
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.
Richard D. Ye,François Boulay,Ji Ming Wang,Claes Dahlgren,Craig Gerard,Marc Parmentier,Charles N. Serhan,Philip M. Murphy +7 more
TL;DR: An International Union of Basic and Clinical Pharmacology (IUPHAR)-recommended nomenclature is introduced and unmet challenges are discussed, including the mechanisms used by these receptors to bind diverse ligands and mediate different biological functions.
Journal ArticleDOI
Microglia and neurodegeneration: The role of systemic inflammation
TL;DR: It is now apparent in multiple chronic disease states, and in ageing, that microglia are primed by prior pathology, or by genetic predisposition, to respond more vigorously to subsequent inflammatory stimulation, thus transforming an adaptive CNS inflammatory response to systemic inflammation, into one that has deleterious consequences for the individual.
Journal ArticleDOI
CB2 receptors in the brain: role in central immune function
TL;DR: In vivo and in vitro, the exogenous cannabinoids delta‐9‐tetrahydrocannabinol and CP55940 inhibit the chemotactic response of microglia to Acanthamoeba culbertsoni, an opportunistic pathogen that is the causative agent of Granulomatous Amoebic Encephalitis through activation of the CB2R.
Journal ArticleDOI
The methodology of TSPO imaging with positron emission tomography.
Federico Turkheimer,Gaia Rizzo,Peter S. Bloomfield,Oliver D. Howes,Oliver D. Howes,Paolo Zanotti-Fregonara,Alessandra Bertoldo,Mattia Veronese +7 more
TL;DR: The main methodological aspects of TSPO PET imaging are reviewed with particular attention to TspO genetics, cellular heterogeneity of T SPO in brain tissue and TSPo distribution in blood and plasma that need to be considered in the quantification of PET data to avoid spurious results as well as ineffective development and use of these radiotracers.
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