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Novel targets for positron emission tomography (PET) radiopharmaceutical tracers for visualization of neuroinflammation

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TLDR
The review summarizes the developments of various radiolabeled ligands for PET imaging of neuroinflammation, based on detection of isotope labeled tracers, which emit positrons.
Abstract
Non-invasive molecular imaging techniques can enhance diagnosis of neurological diseases to achieve their successful treatment. Positron emission tomography (PET) imaging can identify activated microglia and provide detailed functional information based on molecular biology. This imaging modality is based on detection of isotope labeled tracers, which emit positrons. The review summarizes the developments of various radiolabeled ligands for PET imaging of neuroinflammation.

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Research on system response matrix modelling method of rectangular PET scanner based on Monte Carlo simulation

TL;DR: In this article, the authors proposed a method based on system geometric symmetry to reduce the simulation time and split the symmetry into two types: intra-ring symmetry and inter-axis symmetry, a total of 208 times the symmetry is used.
References
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Journal ArticleDOI

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

TL;DR: This review focuses on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain.
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International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.

TL;DR: An International Union of Basic and Clinical Pharmacology (IUPHAR)-recommended nomenclature is introduced and unmet challenges are discussed, including the mechanisms used by these receptors to bind diverse ligands and mediate different biological functions.
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Microglia and neurodegeneration: The role of systemic inflammation

TL;DR: It is now apparent in multiple chronic disease states, and in ageing, that microglia are primed by prior pathology, or by genetic predisposition, to respond more vigorously to subsequent inflammatory stimulation, thus transforming an adaptive CNS inflammatory response to systemic inflammation, into one that has deleterious consequences for the individual.
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CB2 receptors in the brain: role in central immune function

TL;DR: In vivo and in vitro, the exogenous cannabinoids delta‐9‐tetrahydrocannabinol and CP55940 inhibit the chemotactic response of microglia to Acanthamoeba culbertsoni, an opportunistic pathogen that is the causative agent of Granulomatous Amoebic Encephalitis through activation of the CB2R.
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The methodology of TSPO imaging with positron emission tomography.

TL;DR: The main methodological aspects of TSPO PET imaging are reviewed with particular attention to TspO genetics, cellular heterogeneity of T SPO in brain tissue and TSPo distribution in blood and plasma that need to be considered in the quantification of PET data to avoid spurious results as well as ineffective development and use of these radiotracers.
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