Journal ArticleDOI
Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis.
Reads0
Chats0
TLDR
In this article, the authors investigated the evidence that nutrient and food intake modifies the risk of children developing allergy and found that serum vitamin A was lower in children with asthma compared with controls (odds ratio [OR], 0.25; 95% CI, 0.10-0.40).Abstract:
Background Epidemiologic studies suggest that deficiencies of the nutrients selenium; zinc; vitamins A, C, D, and E; and low fruit and vegetable intake may be associated with the development of asthma and allergic disorders. Objectives To investigate the evidence that nutrient and food intake modifies the risk of children developing allergy. Methods We systematically searched 11 databases. Studies were critically appraised, and meta-analyses were undertaken. Results We identified 62 eligible reports. There were no randomized controlled trials. Studies used cohort (n = 21), case-control (n = 15), or cross-sectional (n = 26) designs. All studies were judged to be at moderate to substantial risk of bias. Meta-analysis revealed that serum vitamin A was lower in children with asthma compared with controls (odds ratio [OR], 0.25; 95% CI, 0.10-0.40). Meta-analyses also showed that high maternal dietary vitamin D and E intakes during pregnancy were protective for the development of wheezing outcomes (OR, 0.56, 95% CI, 0.42-0.73; and OR, 0.68, 95% CI, 0.52-0.88, respectively). Adherence to a Mediterranean diet was protective for persistent wheeze (OR, 0.22; 95% CI, 0.08-0.58) and atopy (OR, 0.55; 95% CI, 0.31-0.97). Seventeen of 22 fruit and vegetable studies reported beneficial associations with asthma and allergic outcomes. Results were not supportive for other allergic outcomes for these vitamins or nutrients, or for any outcomes in relation to vitamin C and selenium. Conclusion: The available epidemiologic evidence is weak but nonetheless supportive with respect to vitamins A, D, and E; zinc; fruits and vegetables; and a Mediterranean diet for the prevention of asthma. Experimental studies of these exposures are now warranted.read more
Citations
More filters
Journal ArticleDOI
Critical review: vegetables and fruit in the prevention of chronic diseases
Heiner Boeing,Angela Bechthold,Achim Bub,Sabine Ellinger,Dirk Haller,Anja Kroke,Eva Leschik-Bonnet,Manfred J. Müller,H Oberritter,Matthias B. Schulze,Peter Stehle,Bernhard Watzl +11 more
TL;DR: This critical review on the associations between the intake of vegetables and fruit and the risk of several chronic diseases shows that a high daily intake of these foods promotes health.
Journal ArticleDOI
Risk factors for asthma: is prevention possible?
TL;DR: A better understanding of the factors that cause asthma is urgently needed, and this knowledge could be used to develop public health and pharmacological primary prevention measures that are effective in reducing the prevalence of asthma worldwide.
Journal ArticleDOI
The biodiversity hypothesis and allergic disease: world allergy organization position statement
Tari Haahtela,Stephen T. Holgate,Ruby Pawankar,Cezmi A. Akdis,Suwat Benjaponpitak,Luis Caraballo,Jeffrey G. Demain,Jay M. Portnoy,Leena von Hertzen +8 more
TL;DR: It is proposed that biodiversity, the variability among living organisms from all sources are closely related, at both the macro- and micro- Levels, and loss of the macrodiversity is associated with shrinking of the microdiversity, which is associatedwith alterations of the indigenous microbiota.
Journal ArticleDOI
Preterm Birth and Childhood Wheezing Disorders: A Systematic Review and Meta-Analysis
Jasper V Been,Marlies J. Lugtenberg,Eline Smets,Constant P van Schayck,Boris W. Kramer,Monique Mommers,Aziz Sheikh,Aziz Sheikh,Aziz Sheikh +8 more
TL;DR: In a systematic review and meta-analysis, Jasper Been and colleagues investigate the association between preterm birth and the development of wheezing disorders in childhood.
Journal ArticleDOI
The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces
TL;DR: A comprehensive review on the impact of westernized diet and associated nutrients on immune cell responses and the microbiota and how these can influence the pathology of IBD and asthma is provided.
References
More filters
Journal ArticleDOI
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal Article
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee.
TL;DR: The variation in the prevalences of asthma, allergic rhinoconjunctivitis, and atopic-eczema symptoms is striking between different centres throughout the world and will form the basis of further studies to investigate factors that potentially lead to these international patterns.
Journal ArticleDOI
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC
TL;DR: In this article, the authors investigated worldwide prevalence of asthma, allergic rhinoconjunctivitis, and atopic disorders in children, and found differences of between 20-fold and 60-fold between centres in the prevalence of symptoms of asthma.
Journal ArticleDOI
Discrepancies between Meta-Analyses and Subsequent Large Randomized, Controlled Trials
TL;DR: The outcomes of the 12 large randomized, controlled trials that were studied were not predicted accurately 35 percent of the time by the meta-analyses published previously on the same topics.