Occupational risk factors in Alzheimer's disease: a review assessing the quality of published epidemiological studies.
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TLDR
Epidemiological evidence of an association between Alzheimers disease AD and the most frequently studied occupational exposures pesticides, solvents, electromagnetic fields EMF, lead and aluminium is inconsistent.Abstract:
Epidemiological evidence of an association between Alzheimer's disease (AD) and the most frequently studied occupational exposures—pesticides, solvents, electromagnetic fields (EMF), lead and aluminium—is inconsistent. Epidemiological studies published up to June of 2003 were systematically searched through PubMed and Toxline. Twenty‐four studies (21 case–control and 3 cohort studies) were included. Median GQI was 36.6% (range 19.5–62.9%). Most of the case–control studies had a GQI of <50%. The study with the highest score was a cohort study. Likelihood of exposure misclassification bias affected 18 of the 24 studies. Opportunity for bias arising from the use of surrogate informants affected 17 studies, followed by disease misclassification (11 studies) and selection bias (10 studies). Eleven studies explored the relationship of AD with solvents, seven with EMF, six with pesticides, six with lead and three with aluminium. For pesticides, studies of greater quality and prospective design found increased and statistically significant associations. For the remaining occupational agents, the evidence of association is less consistent (for solvents and EMF) or absent (for lead and aluminium).read more
Citations
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Journal ArticleDOI
Occupational exposure to pesticides increases the risk of incident AD: The Cache County Study
Kathleen M. Hayden,Maria C. Norton,Dennis J. Darcey,Truls Østbye,Peter P. Zandi,John C.S. Breitner,Kathleen A. Welsh-Bohmer +6 more
TL;DR: Pesticide exposure may increase the risk of dementia and Alzheimer disease in late life, particularly in those aged 65 years and older.
Journal ArticleDOI
Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts.
Calvin C. Willhite,Nataliya A. Karyakina,Robert A. Yokel,Nagarajkumar Yenugadhati,Thomas Wisniewski,Ian Arnold,Franco Momoli,Daniel Krewski +7 more
TL;DR: There is no consistent and convincing evidence to associate the Al found in food and drinking water at the doses and chemical forms presently consumed by people living in North America and Western Europe with increased risk for Alzheimer's disease (AD), and there is there clear evidence to show use of Al-containing underarm antiperspirants or cosmetics increases the risk of AD or breast cancer.
Journal Article
The Canadian Study of Health and Aging
TL;DR: This study confirmed a number of previously reported risk factors for AD, but provided little support for others; a new finding was an increased risk for those with occupational exposure to glues as well as pesticides and fertilizers, but this needs further study.
Journal ArticleDOI
Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases.
Lucia Migliore,Fabio Coppedè +1 more
TL;DR: Recent advances in the understanding of the interaction between genetics and environmental factors involved in complex multi-factorial neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis are summarized.
Journal ArticleDOI
Environmental risk factors for dementia: a systematic review.
TL;DR: This extensive review suggests that future research could focus on a short list of environmental risk factors for dementia, and further robust, longitudinal studies with repeated measures of environmental exposures are required to confirm these associations.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Meta-analysis of Observational Studies in Epidemiology
Journal ArticleDOI
Alzheimer's disease: A study of epidemiological aspects
Albert Heyman,William E. Wilkinson,Judith A. Stafford,Michael J. Helms,Alverta H. Sigmon,Tina Weinberg +5 more
TL;DR: There appeared to be no major premorbid demographic or clinical factors associated with this form of dementia, and there was evidence, however, of a genetic factor that was manifested in an excess of dementia and mental retardation in families of patients with Alzheimer's disease.
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