Olfactory Disorders and Quality of Life—An Updated Review
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TLDR
It can be concluded that loss of the sense of smell leads to disturbances in important areas, mainly in food enjoyment, detecting harmful food and smoke, and to some extent in social situations and working life.Abstract:
Olfactory disorders are common and affect about one-fifth of the general population. The main causes of olfactory loss are post viral upper respiratory infection, nasal/sinus disease, and head trauma and are therefore very frequent among patients in ear, nose, and throat clinics. We have systematically reviewed the impact of quantitative, qualitative, and congenital olfactory disorders on daily life domains as well as on general quality of life and depression. From the extensive body of literature, it can be concluded that loss of the sense of smell leads to disturbances in important areas, mainly in food enjoyment, detecting harmful food and smoke, and to some extent in social situations and working life. Most patients seem to deal well and manage those restrictions. However, a smaller proportion has considerable problems and expresses a noticeable reduction in general quality of life and enhanced depression. The impact of coping strategies is discussed.read more
Citations
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Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients
TL;DR: This article analyzed bulk and single cell RNA-Seq datasets to identify cell types in the olfactory epithelium that express molecules that mediate infection by SARS-CoV-2 (CoV2), the causal agent in COVID-19.
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The Association Between Olfaction and Depression: A Systematic Review
TL;DR: Patients with depression have reduced Olfactory performance when compared with the healthy controls and conversely, patients with olfactory dysfunction, have symptoms of depression that worsen with severity of smell loss.
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Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
David H. Brann,Tatsuya Tsukahara,Caleb Weinreb,Marcela Lipovsek,Koen Van den Berge,Boying Gong,Rebecca K. Chance,Iain C. Macaulay,Hsin-jung Chou,Russell B. Fletcher,Diya Das,Kelly Street,Hector Roux de Bézieux,Yoon Gi Choi,Davide Risso,Sandrine Dudoit,Elizabeth Purdom,Jonathan Mill,Ralph Abi Hachem,Hiroaki Matsunami,Darren W. Logan,Bradley J. Goldstein,Matthew S. Grubb,John Ngai,John Ngai,Sandeep Robert Datta +25 more
TL;DR: Findings suggest that CoV-2 infection of non-neuronal cell types leads to anosmia and related disturbances in odor perception in COVID-19 patients.
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Anosmia-A Clinical Review.
Sanne Boesveldt,Elbrich M. Postma,Duncan Boak,Antje Welge-Luessen,Veronika Schöpf,Joel D. Mainland,Joel D. Mainland,Jeffrey R. Martens,John Ngai,Valerie B. Duffy +9 more
TL;DR: Details of feasible and useful screening measures for olfactory dysfunction, appropriate clinical evaluation, and patient counseling to avoid harm as well as manage health and quality of life with anosmia are reported and extended.
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