Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics.
Marlene M. Speth,Thirza Singer-Cornelius,Michael Oberle,Isabelle Gengler,Steffi J. Brockmeier,Ahmad R. Sedaghat +5 more
TLDR
OD is highly prevalent during COVID-19, occurring early and severely, often in conjunction with loss of taste, and is associated negatively with older age and positively with female sex.Abstract:
ObjectiveOlfactory dysfunction (OD)—hyposmia or anosmia—is a symptom of coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-C...read more
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Organ-specific manifestations of COVID-19 infection.
Maria Gavriatopoulou,Eleni Korompoki,Eleni Korompoki,Despina Fotiou,Ioannis Ntanasis-Stathopoulos,Theodora Psaltopoulou,Efstathios Kastritis,Evangelos Terpos,Meletios A. Dimopoulos +8 more
TL;DR: A comprehensive overview of the organ-specific systemic manifestations of COVID-19 is provided, showing that over a third of infected patients develop a broad spectrum of neurological symptoms affecting the central nervous system, peripheral nervous system and skeletal muscles, including anosmia and ageusia.
Journal ArticleDOI
Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences.
TL;DR: The finding of geographic differences points to two, not mutually exclusive causes: a virus mutation (D614G) may cause differing infectivity, while, at the host level, genetic, ethnicity-specific variants of the virus-binding entry proteins may facilitate virus entry in the olfactory epithelium and taste buds.
Journal ArticleDOI
Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients.
Jerome R. Lechien,Carlos M. Chiesa-Estomba,Eline Beckers,Vincent Mustin,Morgane Ducarme,Fabrice Journe,Arnaud Marchant,Lionel Jouffe,Maria Rosaria Barillari,Giovanni Cammaroto,Marta P. Circiu,Stéphane Hans,Sven Saussez,Sven Saussez +13 more
TL;DR: In this article, the authors investigated prevalence and recovery of olfactory dysfunction in COVID-19 patients according to the disease severity and found that the prevalence of OD was significantly higher in mild form (85.9%) compared with moderate-to-critical forms (4.5-6.9%).
Journal ArticleDOI
Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions.
T. T. Favas,Priya Dev,Rameshwar Nath Chaurasia,Kamlesh Chakravarty,Rahul Mishra,Deepika Joshi,Vijay Nath Mishra,Anand Kumar,Varun Kumar Singh,Manoj Pandey,Abhishek Pathak +10 more
TL;DR: Identifying some neurological manifestations like smell and taste disturbances can be used to screen patients with COVID-19 so that early identification and isolation is possible.
Journal ArticleDOI
Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 (COVID-19): A Meta-analysis of 27,492 Patients.
TL;DR: A systematic review and meta‐analysis was conducted to estimate the overall pooled prevalence of olfactory dysfunction in COVID‐19 patients and found that it was higher in women than in men.
References
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Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients.
Lirong Zou,Feng Ruan,Mingxing Huang,Lijun Liang,Huitao Huang,Zhongsi Hong,Jianxiang Yu,Min Kang,Yingchao Song,Jinyu Xia,Qianfang Guo,Tie Song,Jianfeng He,Hui-Ling Yen,Malik Peiris,Jie Wu +15 more
TL;DR: Results of an analysis of nasal and throat swabs from 17 patients in Zhuhai, China, who had received a diagnosis of Covid-19 and found SARS-CoV-2 Viral Load in Upper Respiratory Specimens positive.
Journal ArticleDOI
Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.
Jerome R. Lechien,Carlos M. Chiesa-Estomba,Daniele R De Siati,Mihaela Horoi,Serge D Le Bon,Alexandra Rodriguez,Didier Dequanter,Serge Blecic,Fahd El Afia,Lea Distinguin,Younes Chekkoury-Idrissi,Stéphane Hans,Irene Lopez Delgado,Christian Calvo-Henriquez,Philippe Lavigne,Chiara Falanga,Maria Rosaria Barillari,Giovanni Cammaroto,Mohamad Khalife,Pierre Leich,Christel Souchay,Camelia Rossi,Fabrice Journe,Julien Hsieh,Myriam Edjlali,Myriam Edjlali,Robert Carlier,Laurence Ris,Andrea Lovato,Cosimo de Filippis,Frédérique Coppée,Nicolas Fakhry,Tareck Ayad,Sven Saussez +33 more
TL;DR: Olfactory and gustatory disorders are prevalent symptoms in European CO VID-19 patients, who may not have nasal symptoms, and the sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.
Journal ArticleDOI
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Waradon Sungnak,Ni Huang,Christophe Bécavin,Marijn Berg,Rachel Queen,Monika Litvinukova,Monika Litvinukova,Carlos Talavera-López,Henrike Maatz,Daniel Reichart,Fotios Sampaziotis,Kaylee B Worlock,Masahiro Yoshida,Josephine Barnes +13 more
TL;DR: In this paper, the expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors was investigated, and co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission.
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