On the effects of membrane viscosity on transient red blood cell dynamics
Fabio Guglietta,Fabio Guglietta,Fabio Guglietta,Marek Behr,Luca Biferale,Giacomo Falcucci,Mauro Sbragaglia +6 more
TLDR
In this paper, the authors studied the time-dependent response of an erythrocyte membrane to external mechanical loads via ab-initio, mesoscale numerical simulations, with a primary focus on the detailed characterisation of the RBC relaxation time following the arrest of the external mechanical load.Abstract:
Computational Fluid Dynamics (CFD) is currently used to design and improve the hydraulic properties of biomedical devices, wherein the large scale blood circulation needs to be simulated by accounting for the mechanical response of red blood cells (RBCs) at mesoscales. In many practical instances, biomedical devices work on time-scales comparable to the intrinsic relaxation time of RBCs: thus, a systematic understanding of the time-dependent response of erythrocyte membranes is crucial for the effective design of such devices. So far, this information has been deduced from experimental data, which do not necessarily adapt to the the broad variety of the fluid dynamic conditions that can be encountered in practice. This work explores the novel possibility of studying the time-dependent response of an erythrocyte membrane to external mechanical loads via ab-initio, mesoscale numerical simulations, with a primary focus on the detailed characterisation of the RBC relaxation time $t_c$ following the arrest of the external mechanical load. The adopted mesoscale model exploits a hybrid Immersed Boundary-Lattice Boltzmann Method (IB-LBM), coupled with the Standard Linear Solid model (SLS) to account for the RBC membrane viscosity. We underscore the key importance of the 2D membrane viscosity $\mu_{m}$ to correctly reproduce the relaxation time of the RBC membrane. A detailed assessment of the dependencies on the typology and strength of the applied mechanical loads is also provided. Overall, our findings open interesting future perspectives for the study of the non-linear response of RBCs immersed in time-dependent strain fields.read more
Citations
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Computational interfacial rheology
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A Lattice Boltzmann dynamic-Immersed Boundary scheme for the transport of deformable inertial capsules in low-Re flows
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Impact of the membrane viscosity on the tank-treading behavior of red blood cells
TL;DR: In this paper, the authors compared the impact of the internal fluid viscosity and the membrane viscosities on an isolated tank-treading red blood cell and found that both decrease the tank treading frequency, with moderate changes in the deformation and inclination of the red blood cells.
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Lattice Boltzmann simulations on the tumbling to tank-treading transition: effects of membrane viscosity
TL;DR: It is found that, at fixed viscosity ratios λ, larger values of μm lead to an increased range of values of capillary number at which the TB-TT transition occurs; moreover, increasing λ or increasing μm results in a qualitatively but not quantitatively similar behaviour.
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Red blood cell shape transitions and dynamics in time-dependent capillary flows
TL;DR: In this article , the authors explore the dynamics and shape transitions of RBCs on the cellular scale under confined and unsteady flow conditions using a combination of microfluidic experiments and numerical simulations.
References
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Journal ArticleDOI
Elastic Properties of Lipid Bilayers: Theory and Possible Experiments
TL;DR: A theory of the elasticity of lipid bilayers is proposed and it is argued that in the case of vesicles (= closed bilayer films) the only elasticity controlling nonspherical shapes is that of curvature.
Journal ArticleDOI
The Lattice Boltzmann Equation for Fluid Dynamics and Beyond by Sauro Succi (Clarendon Press, Oxford, 2001) ISBN 0 19 850398 9
Journal ArticleDOI
Biomechanics: Mechanical Properties of Living Tissues
Yuan-Cheng Fung,Richard Skalak +1 more
TL;DR: In this article, the authors present a sketch of the history and scope of the field of bio-physiology and discuss the meaning of the Constitutive Equation and the flow properties of blood.
Journal ArticleDOI
Discrete lattice effects on the forcing term in the lattice Boltzmann method
TL;DR: It is shown that discrete lattice effects must be considered in the introduction of a force into the lattice Boltzmann equation, and a representation of the forcing term is proposed that derived the Navier-Stokes equation through the Chapman-Enskog expansion.
Journal ArticleDOI
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
Subra Suresh,Joachim P. Spatz,J. P. Mills,Alexandre Micoulet,Ming Dao,Chwee Teck Lim,Michael Beil,T. Seufferlein +7 more
TL;DR: Comparing and contrast chemomechanical pathways whereby intracellular structural rearrangements lead to global changes in mechanical deformability of the cell, and examining the biochemical conditions mediating increases or decreases in modulus, and their implications for disease progression are compared.